Evidence map›Paper›PMID 25937888›Full record

ArticleJournal of clinical bioinformatics2015

Comparative efficacy and acceptability of five anti-tubercular drugs in treatment of multidrug resistant tuberculosis: a network meta-analysis.

Huaidong Wang, Xiaotian Zhang, Yuanxiang Bai, Zipeng Duan, Yan Lin, Guoqing Wang, Fan Li

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of clinical bioinformatics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
1.2field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it, 3 citations in OpenAlex.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Huaidong WangKey Laboratory of Zoonosis, Ministry of Education, College of Basic Medicine, Jilin University, 126 Xinmin Street, Changchun, Jilin China.
Xiaotian ZhangKey Laboratory of Zoonosis, Ministry of Education, College of Basic Medicine, Jilin University, 126 Xinmin Street, Changchun, Jilin China.
Yuanxiang BaiKey Laboratory of Zoonosis, Ministry of Education, College of Basic Medicine, Jilin University, 126 Xinmin Street, Changchun, Jilin China.
Zipeng DuanKey Laboratory of Zoonosis, Ministry of Education, College of Basic Medicine, Jilin University, 126 Xinmin Street, Changchun, Jilin China.
Yan LinKey Laboratory of Zoonosis, Ministry of Education, College of Basic Medicine, Jilin University, 126 Xinmin Street, Changchun, Jilin China.
Guoqing WangKey Laboratory of Zoonosis, Ministry of Education, College of Basic Medicine, Jilin University, 126 Xinmin Street, Changchun, Jilin China.
Fan LiKey Laboratory of Zoonosis, Ministry of Education, College of Basic Medicine, Jilin University, 126 Xinmin Street, Changchun, Jilin China.
Jilin University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Multidrug resistant tuberculosis (MDR-TB) is a serious form of tuberculosis (TB). There is no recognized effective treatment for MDR-TB, although there are a number of publications that have reported positive results for MDR-TB. We performed a network meta-analysis to assess the efficacy and acceptability of potential antitubercular drugs. We conducted a network meta-analysis of randomized controlled clinical trials to compare the efficacy and acceptability of five antitubercular drugs, bedaquiline, delamanid, levofloxacin, metronidazole and moxifloxacin in the treatment of MDR-TB. We included eleven suitable trials from nine journal articles and six clinical trials from ClinicalTrials.gov, with data for 1472 participants. Bedaquiline (odds ratio [OR] 2.69, 95% CI 1.02-7.43), delamanid (OR 2.45, 95% CI 1.36-4.89) and moxifloxacin (OR 2.47, 95% CI 1.01, 7.31) were significantly more effective than placebo. For efficacy, the results indicated no statistical significance between each antitubercular drug. For acceptability, the results indicated no statistically significant difference between each compared intervention. There is insufficient evidence to suggest that any one of the five antitubercular drugs (bedaquiline, delamanid, levofloxacin, metronidazole and moxifloxacin) has superior efficacy compared to the others.

Indexed as

Antitubercular drugsMultidrug-resistant tuberculosisNetwork meta-analysis

Identifiers

PMID25937888
PMCPMC4416256
OpenAlexW2030996525

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.