Evidence map›Paper›PMID 25937774›Full record

ReviewChinese journal of cancer research = Chung-kuo yen cheng yen chiu2015

The status, limitation and improvement of adoptive cellular immunotherapy in advanced urologic malignancies.

Haoqing Shi, Xiangjie Qi, Bin Ma, Yanwei Cao, Lina Wang, Lijiang Sun, Haitao Niu

Abstract readReview
In one paragraph

Review in Chinese journal of cancer research = Chung-kuo yen cheng yen chiu, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.1field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 15 citations in OpenAlex.

  1. Review
  2. CD137Cancers · 2021
    Review
  3. Review
  4. Article
  5. Immunogenic Effect of Hyperthermia on Enhancing Radiotherapeutic Efficacy.International journal of molecular sciences · 2018
    Review
  6. Article
  7. Article
  8. Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Haoqing Shi1 Department of Urology, Affiliated Hospital of Qingdao University, Qingdao 266003, China ; 2 Department of Urology, People's Hospital of Linzi District, Zibo 255400, China ; 3 Medical College of Qingdao University, Qingdao 266021, China.
Xiangjie Qi1 Department of Urology, Affiliated Hospital of Qingdao University, Qingdao 266003, China ; 2 Department of Urology, People's Hospital of Linzi District, Zibo 255400, China ; 3 Medical College of Qingdao University, Qingdao 266021, China.
Bin Ma1 Department of Urology, Affiliated Hospital of Qingdao University, Qingdao 266003, China ; 2 Department of Urology, People's Hospital of Linzi District, Zibo 255400, China ; 3 Medical College of Qingdao University, Qingdao 266021, China.
Yanwei Cao1 Department of Urology, Affiliated Hospital of Qingdao University, Qingdao 266003, China ; 2 Department of Urology, People's Hospital of Linzi District, Zibo 255400, China ; 3 Medical College of Qingdao University, Qingdao 266021, China.
Lina Wang1 Department of Urology, Affiliated Hospital of Qingdao University, Qingdao 266003, China ; 2 Department of Urology, People's Hospital of Linzi District, Zibo 255400, China ; 3 Medical College of Qingdao University, Qingdao 266021, China.
Lijiang Sun1 Department of Urology, Affiliated Hospital of Qingdao University, Qingdao 266003, China ; 2 Department of Urology, People's Hospital of Linzi District, Zibo 255400, China ; 3 Medical College of Qingdao University, Qingdao 266021, China.
Haitao Niu1 Department of Urology, Affiliated Hospital of Qingdao University, Qingdao 266003, China ; 2 Department of Urology, People's Hospital of Linzi District, Zibo 255400, China ; 3 Medical College of Qingdao University, Qingdao 266021, China.
Qingdao University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In recent years, immunotherapy has been gradually established as the fourth frequently adopted antitumor therapy, following surgery, chemotherapy and radiotherapy, for advanced urologic malignancies with an improved understanding of theoretical basis, such as molecular biology and immunology. Thereinto, adoptive cellular immunotherapy (ACI) has become one of the hotspots, which comprises a variety of treatment approaches, such as TIL, CIK cell, γδ T cell, CAR-engineered T cell and Allogeneic stem cell transplantation (alloSCT). Although preclinical efficacy has been demonstrated remarkably, clinical trials could not consistently show the benefit due to multi-factors in complex immunosuppressive microenvironment in vivo compared to that of in vitro. Here we review some timely aspects of ACI for advanced urologic malignancies, and describe the current status and limitation of immunotherapy from the cellular level. It's our expectation to provide prompting consideration of novel combinatorial ACI strategies and a resurgence of interest in ACI for advanced urologic malignancies.

Indexed as

Adoptive cellular immunotherapy (ACI)improvementlimitationurologic malignancies

Identifiers

PMID25937774
PMCPMC4409967
OpenAlexW1570644230

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.