ArticleEuropean polymer journal2015
Degradable PEGylated Protein Conjugates Utilizing RAFT Polymerization.
Article in European polymer journal, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Effects of LinTT1-peptide conjugation on the properties of poly(ethylene glycol)-block-(ε-caprolactone) nanoparticles prepared by the nanoprecipitation method.Drug delivery and translational research · 2025Article
- Main chain selective polymer degradation: controlled by the wavelength and assembly.Chemical science · 2024Article
- Reversible Polymer-Protein Functionalization by Stepwise Introduction of Amine-Reactive, Reductive-Responsive Self-Immolative End Groups onto RAFT-Derived Polymers.ACS biomaterials science & engineering · 2024Article
- Article
- Degradable Polyampholytes from Radical Ring-Opening Copolymerization Enhance Cellular Cryopreservation.ACS macro letters · 2022Article
- RAFT-Based Polymers for Click Reactions.Polymers · 2022Review
- Two-distinct polymer ubiquitin conjugates by photochemical grafting-from.Macromolecular chemistry and physics · 2021Article
- Article
- A guide to maximizing the therapeutic potential of protein-polymer conjugates by rational design.Chemical Society reviews · 2018Review
- Synthesis and Biological Evaluation of a Degradable Trehalose Glycopolymer Prepared by RAFT Polymerization.Macromolecular rapid communications · 2018Article
- Degradable copolymers with incorporated ester groups by radical ring-opening polymerization using atom transfer radical polymerization.Polimery · 2017Article
- Heparin-Mimicking Polymers: Synthesis and Biological Applications.Biomacromolecules · 2016Review
- Degradable vinyl polymers for biomedical applications.Nature chemistry · 2015Review
- Functional Degradable Polymers by Radical Ring-Opening Copolymerization of MDO and Vinyl Bromobutanoate: Synthesis, Degradability and Post-Polymerization Modification.Biomacromolecules · 2015Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Poly(ethylene glycol) (PEG)-protein therapeutics exhibit enhanced pharmacokinetics, but have drawbacks including decreased protein activities and polymer accumulation in the body. Therefore a major aim for second-generation polymer therapeutics is to introduce degradability into the backbone. Herein we describe the synthesis of poly(poly(ethylene glycol methyl ether methacrylate)) (pPEGMA) degradable polymers with protein-reactive end-groups via reversible addition-fragmentation chain transfer (RAFT) polymerization, and the subsequent covalent attachment to lysozyme through a reducible disulfide linkage. RAFT copolymerization of cyclic ketene acetal (CKA) monomer 5,6-benzo-2-methylene-1,3-dioxepane (BMDO) with PEGMA yielded two polymers with number-average molecular weight (
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.