Evidence map›Paper›PMID 25937599›Full record

ReviewPeptides2015

Peptides at the blood brain barrier: Knowing me knowing you.

Thomas P Davis, Thomas J Abbruscato, Richard D Egleton

Abstract readHistorical ArticleReview
In one paragraph

Review in Peptides, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Review
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Thomas P DavisThe Davis Lab, Department of Medical Pharmacology, University of Arizona, Tucson, AZ 85724-5050. Electronic address: davistp@email.arizona.edu.
Thomas J AbbruscatoTexas Tech University Health Sciences Center, School of Pharmacy, Amarillo, TX 79106.
Richard D EgletonJoan C. Edwards School of Medicine at Marshall University, Huntington, WV 25755.

Funding

BLOOD BRAIN BARRIER CHANGES INDUCED BY PAINR01NS042652 · NINDS · UNIVERSITY OF ARIZONA · PI DAVIS, THOMAS PAUL · 2002 to 2017
$7.6M
BLOOD TO CNS UPTAKE OF OPIOID PEPTIDE DRUGSR01DA011271 · NIDA · UNIVERSITY OF ARIZONA · PI DAVIS, THOMAS PAUL · 1997 to 2014
$4.4M
Increased sodium dependent glucose transport in the ischemic brainR01NS076012 · NINDS · TEXAS TECH UNIVERSITY HEALTH SCIS CENTER · PI ABBRUSCATO, THOMAS J · 2011 to 2015
$1.5M
NIDA NIH HHS 5R01 DA011271NIDA NIH HHS R01 DA011271NINDS NIH HHS 5R01 NS042652NINDS NIH HHS R01 NS042652NINDS NIH HHS R01 NS076012
6 · The paper itself

Abstract

When the Davis Lab was first asked to contribute to this special edition of Peptides to celebrate the career and influence of Abba Kastin on peptide research, it felt like a daunting task. It is difficult to really understand and appreciate the influence that Abba has had, not only on a generation of peptide researchers, but also on the field of blood brain barrier (BBB) research, unless you lived it as we did. When we look back at our careers and those of our former students, one can truly see that several of Abba's papers played an influential role in the development of our personal research programs.

Indexed as

AnimalsBiomedical ResearchBlood-Brain BarrierHistory, 20th CenturyHistory, 21st CenturyHumansPeptidesProtein TransportPeptidesBlood brain barrierDrug deliveryNeuropeptidesP-glycoproteinTight junction proteinsTransporter proteins

Identifiers

PMID25937599
PMCPMC4627938

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.