ArticleFolia microbiologica2015
In vitro effects on biofilm viability and antibacterial and antiadherent activities of silymarin.
Article in Folia microbiologica, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Silybum marianum against multidrug-resistant bacterial pathogens: mechanisms of action, synergistic therapy, nanoformulations, and clinical translation.Archives of microbiology · 2026Review
- Control of Dental Plaque and Gingival Inflammation by Natural Ingredients-Based Mouthwash.Dentistry journal · 2025Article
- Article
- Quercetin and Silybin Decrease Intracellular Replication ofInternational journal of molecular sciences · 2025Article
- Synergistic effects of silybin and curcumin on virulence and carbapenemase genes expression in multidrug resistant Klebsiella oxytoca.BMC research notes · 2022Article
- Silymarin Modulates Microbiota in the Gut to Improve the Health of Sow from Late Gestation to Lactation.Animals : an open access journal from MDPI · 2022Article
- Silymarin from Milk Thistle Fruits Counteracts Selected Pathological Changes in the Lenses of Type 1 Diabetic Rats.Nutrients · 2022Article
- Effects of Curcumin and Silymarin on the Shigella dysenteriae and Campylobacter jejuni In vitro.Journal of gastrointestinal cancer · 2020Article
- Antibacterial and Antibiofilm Activity of Myrtenol againstPharmaceuticals (Basel, Switzerland) · 2020Article
- Terpinen-4-ol as an Antibacterial and Antibiofilm Agent againstInternational journal of molecular sciences · 2020Article
- Biotransformation of Silymarin Flavonolignans by Human Fecal Microbiota.Metabolites · 2020Article
- Anti-histaminic Effects of Resveratrol and Silymarin on Human Gingival Fibroblasts.Inflammation · 2019Article
- Anti-quorum sensing and anti-biofilm activity ofSaudi journal of biological sciences · 2017Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Limited treatment options in infectious diseases caused by resistant microorganisms created the need to search new approaches. Several herbal extracts are studied for their enormous therapeutic potential. Silymarin extract, from Silybum marianum (milk thistle), is an old and a new remedy for this goal. The purpose of this study is to evaluate the antibacterial and antiadherent effects of silymarin besides biofilm viability activity on standard bacterial strains. Minimal inhibitory concentration (MIC), minimal bactericidal concentration (MBC), antiadherent/antibiofilm activity, and effects on biofilm viability of silymarin were evaluated against standard bacterial strains. MIC values were observed between 60 and >241 μg/mL (0.25->1 mmol/L). Gram-positive bacteria were inhibited at concentrations between 60 and 120 μg/mL. Gram-negative bacteria were not inhibited by the silymarin concentrations included in this study. MBC values for Gram-positive bacteria were greater than 241 μg/mL. Adherence/biofilm formations were decreased to 15 μg/mL silymarin concentration when compared with silymarin-untreated group. Silymarin reduced the biofilm viabilities to 13 and 46 % at 1 and 0.5 mmol/L concentrations, respectively. We demonstrated that silymarin shows antibacterial and antiadherent/antibiofilm activity against certain standard bacterial strains which may be beneficial when used as a dietary supplement or a drug.
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Registered trials
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