ArticleChemistry & biology2015
Structuring Microbial Metabolic Responses to Multiplexed Stimuli via Self-Organizing Metabolomics Maps.
Article in Chemistry & biology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed.
- Discovery of natural products that modulate signaling in patient-derived cells.RSC chemical biology · 2026Article
- Unlocking hidden treasures: the evolution of high-throughput mass spectrometry in screening for cryptic natural products.Natural product reports · 2025Review
- Multiplexed activity metabolomics for isolation of filipin macrolides from a hypogean actinomycete.The Journal of antibiotics · 2025Article
- Article
- Computational Models for Clinical Applications in Personalized Medicine-Guidelines and Recommendations for Data Integration and Model Validation.Journal of personalized medicine · 2022Review
- A Global Metabolic Map Defines the Effects of a Si-Based Biostimulant on Tomato Plants under Normal and Saline Conditions.Metabolites · 2021Article
- A Natural Product Chemist's Guide to Unlocking Silent Biosynthetic Gene Clusters.Annual review of biochemistry · 2021Review
- Article
- Unlocking Cryptic Metabolites with Mass Spectrometry-Guided Transposon Mutant Selection.ACS chemical biology · 2020Article
- Role of symbiosis in the discovery of novel antibiotics.The Journal of antibiotics · 2020Review
- Article
- A genetics-free method for high-throughput discovery of cryptic microbial metabolites.Nature chemical biology · 2019Article
- Response of Secondary Metabolism of Hypogean Actinobacterial Genera to Chemical and Biological Stimuli.Applied and environmental microbiology · 2018Article
- Mining Actinomycetes for Novel Antibiotics in the Omics Era: Are We Ready to Exploit This New Paradigm?Antibiotics (Basel, Switzerland) · 2018Review
- Improving the discovery of secondary metabolite natural products using ion mobility-mass spectrometry.Current opinion in chemical biology · 2018Review
- Microbial Interactions With Dissolved Organic Matter Drive Carbon Dynamics and Community Succession.Frontiers in microbiology · 2018Article
- Microbiome and metabolome data integration provides insight into health and disease.Translational research : the journal of laboratory and clinical medicine · 2017Review
- Natural Product Discovery Using Planes of Principal Component Analysis in R (PoPCAR).Metabolites · 2017Article
- Symbiosis-inspired approaches to antibiotic discovery.Natural product reports · 2017Review
- Natural products as mediators of disease.Natural product reports · 2017Review
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7 authors.
Funding
Abstract
Secondary metabolite biosynthesis in microorganisms responds to discrete chemical and biological stimuli; however, untargeted identification of these responses presents a significant challenge. Herein we apply multiplexed stimuli to Streptomyces coelicolor and collect the resulting response metabolomes via ion mobility-mass spectrometric analysis. Self-organizing map (SOM) analytics adapted for metabolomic data demonstrate efficient characterization of the subsets of primary and secondary metabolites that respond similarly across stimuli. Over 60% of all metabolic features inventoried from responses are either not observed under control conditions or produced at greater than 2-fold increase in abundance in response to at least one of the multiplexing conditions, reflecting how metabolites encode phenotypic changes in an organism responding to multiplexed challenges. Using abundance as an additional filter, each of 16 known S. coelicolor secondary metabolites is prioritized via SOM and observed at increased levels (1.2- to 22-fold compared with unperturbed) in response to one or more challenge conditions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.