Evidence map›Paper›PMID 25937189›Full record

ReviewExpert review of vaccines2015

Adversomics: a new paradigm for vaccine safety and design.

Jennifer A Whitaker, Inna G Ovsyannikova, Gregory A Poland

Open access · greenAbstract readReview
In one paragraph

Review in Expert review of vaccines, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 66 citations in OpenAlex.

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  8. Vaccinomics and adversomics: key elements for a personalized vaccinology.Clinical and experimental vaccine research · 2024
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 2 countries.

Jennifer A WhitakerMayo Clinic Vaccine Research Group, Mayo Clinic, Rochester, MN 55905, USA.
Inna G Ovsyannikova
Gregory A Poland
General Department of Preventive Medicine · VNMayo Clinic in Florida · US

Funding

Bioinformatics Approach to Influenza A/H1N1 Vaccine Immune ProfilingU01AI089859 · NIAID · MAYO CLINIC ROCHESTER · PI POLAND, GREGORY A. · 2010 to 2015
$33.8M
The Immunogenetics of Measles ImmunityR01AI033144 · NIAID · MAYO CLINIC ROCHESTER · PI POLAND, GREGORY A. · 1993 to 2022
$8.1M
Immunogenetic Mechanisms of Vaccine ResponseR37AI048793 · NIAID · MAYO CLINIC ROCHESTER · PI POLAND, GREGORY A. · 2011 to 2020
$5.4M
NIAID NIH HHS N01 AI040065NIAID NIH HHS R01 AI033144NIAID NIH HHS R01AI033144NIAID NIH HHS R37 AI048793NIAID NIH HHS R37AI048793NIAID NIH HHS U01 AI089859NIAID NIH HHS U01AI089859
6 · The paper itself

Abstract

Despite the enormous population benefits of routine vaccination, vaccine adverse events (AEs) and reactions, whether real or perceived, have posed one of the greatest barriers to vaccine acceptance--and thus to infectious disease prevention--worldwide. A truly integrated clinical, translational, and basic science approach is required to understand the mechanisms behind vaccine AEs, predict them, and then apply this knowledge to new vaccine design approaches that decrease, or avoid, these events. The term 'adversomics' was first introduced in 2009 and refers to the study of vaccine adverse reactions using immunogenomics and systems biology approaches. In this review, we present the current state of adversomics research, review known associations and mechanisms of vaccine AEs/reactions, and outline a plan for the further development of this emerging research field.

Indexed as

Patient Acceptance of Health CareBiomedical ResearchDrug-Related Side Effects and Adverse ReactionsHumansImmunogeneticsSystems BiologyVaccinesVaccinesdrug-related side effects and adverse reactionsgenetic association studiesgenomicsimmunogeneticsindividualized medicinepolymorphismsingle nucleotidesystems biologyvaccinationvaccinesviral vaccines

Identifiers

PMID25937189
PMCPMC4630804
OpenAlexW2152808659

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.