Evidence map›Paper›PMID 25936874›Full record

ReviewExperimental neurology2016

Endogenous neurogenic cell response in the mature mammalian brain following traumatic injury.

Dong Sun

Open access · greenAbstract readReview
In one paragraph

Review in Experimental neurology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed
3.7field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 59 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Review
  11. The Adult Neurogenesis Theory of Alzheimer's Disease.Journal of Alzheimer's disease : JAD · 2023
    Article
  12. Article
  13. Article
  14. Therapeutic Application of Stem Cells in the Repair of Traumatic Brain Injury.Stem cells and cloning : advances and applications · 2022
    Review
  15. Review
  16. Review
  17. Polyplex transfection from intracerebroventricular delivery is not significantly affected by traumatic brain injury.Journal of controlled release : official journal of the Controlled Release Society · 2020
    Article
  18. Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Dong SunDepartment of Neurosurgery, Virginia Commonwealth University, P.O. Box 980631, Medical College of Virginia Campus, Richmond, VA 23298-631, USA. Electronic address: dsun@vcu.edu.
Virginia Commonwealth University Medical Center · US

Funding

Modulation of Hippocampal Neurogenesis and Cognitive Recovery Following TraumaR01NS055086 · NINDS · VIRGINIA COMMONWEALTH UNIVERSITY · PI SUN, DONG · 2007 to 2010
$1.2M
Induced Pluripotent Stem Cells from Neurosurgical removed tissue for Brain RepairR21NS078710 · NINDS · VIRGINIA COMMONWEALTH UNIVERSITY · PI RAO, RAJ RAGHAVENDRA, SUN, DONG · 2012 to 2013
$399k
NINDS NIH HHS NS055086NINDS NIH HHS NS078710NINDS NIH HHS R01 NS055086NINDS NIH HHS R21 NS078710
6 · The paper itself

Abstract

In the mature mammalian brain, new neurons are generated throughout life in the neurogenic regions of the subventricular zone (SVZ) and the dentate gyrus (DG) of the hippocampus. Over the past two decades, extensive studies have examined the extent of adult neurogenesis in the SVZ and DG, the role of the adult generated new neurons in normal brain function and the underlying mechanisms regulating the process of adult neurogenesis. The extent and the function of adult neurogenesis under neuropathological conditions have also been explored in varying types of disease models in animals. Increasing evidence has indicated that these endogenous neural stem/progenitor cells may play regenerative and reparative roles in response to CNS injuries or diseases. This review will discuss the potential functions of adult neurogenesis in the injured brain and will describe the recent development of strategies aimed at harnessing this neurogenic capacity in order to repopulate and repair the injured brain following trauma.

Indexed as

NeurogenesisAnimalsBrainBrain InjuriesHumansNeural Stem CellsNeuronsCognitive functionEndogenous neurogenesisHippocampusSubventricular zoneTraumatic brain injury

Identifiers

PMID25936874
PMCPMC4627904
OpenAlexW2035363591

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.