Evidence map›Paper›PMID 25936809›Full record

ArticleInternational journal of radiation oncology, biology, physics2015

Delineation of Supraclavicular Target Volumes in Breast Cancer Radiation Therapy.

Lindsay C Brown, Felix E Diehn, Judy C Boughey, Stephanie K Childs, Sean S Park, Elizabeth S Yan, Ivy A Petersen, Robert W Mutter

Abstract read
PubMed Publisher
In one paragraph

Article in International journal of radiation oncology, biology, physics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
3.4field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 51 citations in OpenAlex.

  1. Trial
  2. Thyroid dose guidance in elective supraclavicular breast radiotherapy: a national survey of practice patterns in Switzerland.Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] · 2026
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  13. A 3-Dimensional Mapping Analysis of Regional Nodal Recurrences in Breast Cancer.International journal of radiation oncology, biology, physics · 2019
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Lindsay C BrownDepartment of Radiation Oncology, Mayo Clinic, Rochester, Minnesota.
Felix E DiehnDepartment of Radiology, Mayo Clinic, Rochester, Minnesota.
Judy C BougheyDepartment of Surgery, Mayo Clinic, Rochester, Minnesota.
Stephanie K ChildsDepartment of Radiation Oncology, Mayo Clinic, Rochester, Minnesota.
Sean S ParkDepartment of Radiation Oncology, Mayo Clinic, Rochester, Minnesota.
Elizabeth S YanDepartment of Radiation Oncology, Mayo Clinic, Rochester, Minnesota.
Ivy A PetersenDepartment of Radiation Oncology, Mayo Clinic, Rochester, Minnesota.
Robert W MutterDepartment of Radiation Oncology, Mayo Clinic, Rochester, Minnesota. Electronic address: mutter.robert@mayo.edu.
Mayo Clinic · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo map the location of gross supraclavicular metastases in patients with breast cancer, in order to determine areas at highest risk of harboring subclinical disease. METHODS AND MATERIALS: Patients with axial imaging of gross supraclavicular disease were identified from an institutional breast cancer registry. Locations of the metastatic lymph nodes were transferred onto representative axial computed tomography images of the supraclavicular region and compared with the Radiation Therapy Oncology Group (RTOG) breast cancer atlas for radiation therapy planning.

resultsSixty-two patients with 161 supraclavicular nodal metastases were eligible for study inclusion. At the time of diagnosis, 117 nodal metastases were present in 44 patients. Forty-four nodal metastases in 18 patients were detected at disease recurrence, 4 of whom had received prior radiation to the supraclavicular fossa. Of the 161 nodal metastases, 95 (59%) were within the RTOG consensus volume, 4 nodal metastases (2%) in 3 patients were marginally within the volume, and 62 nodal metastases (39%) in 30 patients were outside the volume. Supraclavicular disease outside the RTOG consensus volume was located in 3 regions: at the level of the cricoid and thyroid cartilage (superior to the RTOG volume), in the posterolateral supraclavicular fossa (posterolateral to the RTOG volume), and in the lateral low supraclavicular fossa (lateral to the RTOG volume). Only women with multiple supraclavicular metastases had nodal disease that extended superiorly to the level of the thyroid cartilage.

conclusionsFor women with risk of harboring subclinical supraclavicular disease warranting the addition of supraclavicular radiation, coverage of the posterior triangle and the lateral low supraclavicular region should be considered. For women with known supraclavicular disease, extension of neck coverage superior to the cricoid cartilage may be warranted.

Indexed as

AdultAgedAged, 80 and overBreast NeoplasmsClavicleCricoid CartilageFemaleHumansLymphatic IrradiationLymphatic MetastasisLymph NodesMiddle AgedNeoplasm Recurrence, LocalThyroid CartilageTomography, X-Ray Computed

Identifiers

PMID25936809
OpenAlexW2089810107

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.