ArticleMagnetic resonance imaging2015
Dose and pulse sequence considerations for hyperpolarized (129)Xe ventilation MRI.
Article in Magnetic resonance imaging, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01280994 (Hyperpolarized 129Xe MR Imaging of the Lung Function in Healthy Volunteers and Subjects With Pulmonary Disease), which is not on this map. Cited by 39 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Hyperpolarized 129Xe MR Imaging of the Lung Function in Healthy Volunteers and Subjects With Pulmonary Disease
Who cites it
39 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Functional hyperpolarized gas magnetic resonance imaging of idiopathic pulmonary fibrosis: a systematic review.La Radiologia medica · 2026Pooled it
- A Systematic Review of the Variability of Ventilation Defect Percent Generated From Hyperpolarized Noble Gas Pulmonary Magnetic Resonance Imaging.Journal of magnetic resonance imaging : JMRI · 2025Pooled it
- Evaluation of Resorcinarene Trimer Methanesulfonate Aggregation in the Presence of Inorganic Salts and Biomolecules in Aqueous Solutions Using UV-vis Spectroscopy and Electrophoresis.Chemphyschem : a European journal of chemical physics and physical chemistry · 2026Article
- UltrasensitiveAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Review
- Xenon-129 magnetic resonance imaging and spectroscopy detects response to therapy in pulmonary hypertension.The European respiratory journal · 2025Article
- Quantifying Regional Radiation-Induced Lung Injury in Patients Using HyperpolarizedInternational journal of radiation oncology, biology, physics · 2024Article
- HyperpolarizedJHLT open · 2024Article
- Optimized quantitative mapping of cardiopulmonary oscillations using hyperpolarizedMagnetic resonance in medicine · 2024Article
- Acquiring Hyperpolarized 129Xe Magnetic Resonance Images of Lung Ventilation.Journal of visualized experiments : JoVE · 2023Article
- Spin Hyperpolarization in Modern Magnetic Resonance.Chemical reviews · 2023Review
- Comparison of ventilation defects quantified by Technegas SPECT and hyperpolarizedFrontiers in physiology · 2023Article
- Bias field correction in hyperpolarizedMagnetic resonance in medicine · 2022Article
- Standalone portable xenon-129 hyperpolariser for multicentre clinical magnetic resonance imaging of the lungs.The British journal of radiology · 2022Article
- Noninvasive diagnosis of pulmonary hypertension with hyperpolarisedERJ open research · 2022Article
- Utilizing flip angle/TR equivalence to reduce breath hold duration in hyperpolarizedMagnetic resonance in medicine · 2022Article
- Pilot Quality-Assurance Study of a Third-Generation Batch-Mode Clinical-Scale Automated Xenon-129 Hyperpolarizer.Molecules (Basel, Switzerland) · 2022Article
- Enabling Clinical Technologies for HyperpolarizedAngewandte Chemie (International ed. in English) · 2021Review
- HyperpolarizedRadiology · 2021Article
- Regional Gas Exchange Measured byJournal of magnetic resonance imaging : JMRI · 2021Article
- Low-Flammable Parahydrogen-Polarized MRI Contrast Agents.Chemistry (Weinheim an der Bergstrasse, Germany) · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
Abstract
purposeThe aim of this study was to evaluate the effect of hyperpolarized (129)Xe dose on image signal-to-noise ratio (SNR) and ventilation defect conspicuity on both multi-slice gradient echo and isotropic 3D-radially acquired ventilation MRI. MATERIALS AND
methodsTen non-smoking older subjects (ages 60.8±7.9years) underwent hyperpolarized (HP) (129)Xe ventilation MRI using both GRE and 3D-radial acquisitions, each tested using a 71ml (high) and 24ml (low) dose equivalent (DE) of fully polarized, fully enriched (129)Xe. For all images SNR and ventilation defect percentage (VDP) were calculated.
resultsNormalized SNR (SNRn), obtained by dividing SNR by voxel volume and dose was higher for high-DE GRE acquisitions (SNRn=1.9±0.8ml(-2)) than low-DE GRE scans (SNRn=0.8±0.2ml(-2)). Radially acquired images exhibited a more consistent, albeit lower SNRn (High-DE: SNRn=0.5±0.1ml(-2), low-DE: SNRn=0.5±0.2ml(-2)). VDP was indistinguishable across all scans.
conclusionsThese results suggest that images acquired using the high-DE GRE sequence provided the highest SNRn, which was in agreement with previous reports in the literature. 3D-radial images had lower SNRn, but have advantages for visual display, monitoring magnetization dynamics, and visualizing physiological gradients. By evaluating normalized SNR in the context of dose-equivalent formalism, it should be possible to predict (129)Xe dose requirements and quantify the benefits of more efficient transmit/receive coils, field strengths, and pulse sequences.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.