ArticleRespiratory physiology & neurobiology2015
Fentanyl effects on breath generation in C57BL/6J and A/J mouse strains.
Article in Respiratory physiology & neurobiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 18 citations in OpenAlex.
- Carfentanil Depresses Inspiratory Motor Drive.Journal of substance abuse and alcoholism · 2026Article
- Effects of Intravenous Bolus Injection of Fentanyl on Phrenic Nerve Activity and Its Response to Hypoxia and Hypercapnia.Journal of pharmacy and pharmacology research · 2026Article
- Prenatal fentanyl exposure affects social dominance and myelination patterns in the adult mouse brain.Neuropharmacology · 2025Article
- Synthetic cannabinoid receptor agonists exacerbate fentanyl-elicited respiratory depression and confer resistance to naloxone rescue in mice.Drug and alcohol dependence · 2025Article
- An automated respiratory data pipeline for waveform characteristic analysis.The Journal of physiology · 2023Article
- Assessments of perioperative respiratory pattern with non-contact vital sign monitor in children undergoing minor surgery: a prospective observational study.Journal of anesthesia · 2023Observational
- Diet-induced obesity leads to sleep fragmentation independently of the severity of sleep-disordered breathing.Journal of applied physiology (Bethesda, Md. : 1985) · 2022Article
- Buprenorphine differentially alters breathing among four congenic mouse lines as a function of dose, sex, and leptin status.Respiratory physiology & neurobiology · 2022Article
- Fentanyl-induced acute and conditioned behaviors in two inbred mouse lines: Potential role for Glyoxalase.Physiology & behavior · 2022Article
- Intranasal Leptin Prevents Opioid-induced Sleep-disordered Breathing in Obese Mice.American journal of respiratory cell and molecular biology · 2020Article
- Genetic variation regulates opioid-induced respiratory depression in mice.Scientific reports · 2020Article
- Young and middle-aged mouse breathing behavior during the light and dark cycles.Physiological reports · 2019Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
We examined the effect of fentanyl on chemoresponsiveness in mouse strains divergent in the expression of spontaneous and post-hypoxic pauses. Frequency and tidal volume were recorded with plethysmography in A/J and C57BL/6J (B6) male mice. Mice selected at random received an intraperitoneal (IP) injection of either saline, low dose fentanyl (LDF = 0.04 mg/kg), or high dose fentanyl (HDF = 0.4 mg/kg) under hypoxia (8% O2) or hyperoxia (100%O2). LDF produced a decrease in frequency during hypoxia in B6, but not A/J, mice. HDF significantly decreased frequency and tidal volume in both strains under hypoxia and hyperoxia (p<0.01); naloxone, an opioid antagonist, reversed this response. The acute administration of fentanyl at any dose did not promote apneas in strains of mice exhibiting regular or irregular respiratory patterns. However, higher doses depressed respiratory frequency in both strains. The B6 mice responded with a depressive response to hypoxia that did not recover with reoxygenation, but did recover with time or naloxone.
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Registered trials
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