ArticleJournal of gastroenterology2015
Excellent prognosis following endoscopic resection of patients with rectal neuroendocrine tumors despite the frequent presence of lymphovascular invasion.
Article in Journal of gastroenterology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers, 2 of them syntheses that pooled it.
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Who cites it
47 citing papers in PubMed, 2 syntheses or guidelines pooled it, 74 citations in OpenAlex.
- NANETS Guidelines for the diagnosis and management of stage I-III rectal neuroendocrine tumors.Endocrine-related cancer · 2026Guideline
- Pooled it
- Outcomes of subsequent endoscopic resection for rectal neuroendocrine tumors with positive/indeterminate vertical margins.iGIE : innovation, investigation and insights · 2026Article
- Long-Term Outcomes after the Complete Resection of Rectal Neuroendocrine Tumors: A Multicenter Cohort Study.Gut and liver · 2026Article
- Case Report: Apparent progressive complete mismatch repair protein loss during platinum-based chemotherapy in metastatic rectal neuroendocrine tumour grade 2.Frontiers in oncology · 2026Article
- Metachronous Liver Metastasis during Long-term Follow-up after Endoscopic Submucosal Dissection of a Small Rectal Neuroendocrine Neoplasm.Internal medicine (Tokyo, Japan) · 2025Article
- Current status of endoscopic resection for small rectal neuroendocrine tumors.World journal of gastroenterology · 2025Review
- Endoscopic resection of rectal neuroendocrine tumors: zero disease-related deaths during a 10-year follow-up period.BMC gastroenterology · 2025Article
- Recurrence pattern and mapping of lymph node metastases from rectal neuroendocrine tumors.International journal of colorectal disease · 2025Article
- Primary small rectal neuroendocrine tumor with pelvic lateral lymph nodes metastasis: A case report and review of literature.International journal of surgery case reports · 2025Article
- The Association Between Venous Invasion and Distant Metastasis in Head and Neck Squamous Cell Carcinoma.Cureus · 2025Article
- Clinical outcomes after endoscopic resection and the risk of lymph node metastasis in rectal neuroendocrine tumors: a single-center retrospective study.Surgical endoscopy · 2024Article
- The role of endoscopic ultrasonography for diagnosis of residual rectal neuroendocrine tumor.Surgical endoscopy · 2024Article
- Review
- Risk of metastasis and survival in patients undergoing different treatment strategies with T1 colonic neuroendocrine tumors.Journal of endocrinological investigation · 2024Article
- Clinical Value of Clip-and-Snare Assisted Endoscopic Submucosal Resection in Treatment of Rectal Neuroendocrine Tumors.Visceral medicine · 2023Article
- Clinical characteristics and long-term prognosis of type 1 gastric neuroendocrine tumors in a large Japanese national cohort.Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society · 2023Article
- Clinical outcomes and risk factors associated with poor prognosis after endoscopic resection of 10-20 mm rectal neuroendocrine tumors: a multicenter, retrospective study of 10-year experience.Surgical endoscopy · 2023Article
- Long-term clinical outcomes of endoscopic submucosal dissection in rectal neuroendocrine tumors based on resection margin status: a real-world study.Surgical endoscopy · 2023Article
- Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundEndoscopic resection (ER) has been increasingly used for the treatment of rectal neuroendocrine tumors (NETs); however, only limited data are available on its long-term outcomes. This study analyzed the long-term outcomes of rectal NETs treated by ER and characterized potential risk factors for metastasis in these cases, with emphasis on lymphovascular invasion.
methodsWe retrospectively analyzed the clinicopathological features and outcomes of 86 patients with 90 rectal NETs who had been treated by ER. Lymphovascular invasion was reevaluated using elastic-staining and double-staining immunohistochemistry.
resultsEn bloc resection with tumor-free margins was achieved in 87 lesions (96.7%). The median tumor size was 5 mm (range 2-13), and all the lesions were confined to the submucosal layer. The Ki-67 index was less than 3% in all the lesions, which were therefore classified as NET G1. Elastic-staining and double-staining immunohistochemistry revealed the presence of lymphatic and venous invasion in 23 (25.6%) and 35 lesions (36.7%), respectively. Collectively, lymphatic and/or vascular invasion was identified in 42 lesions (46.7%). All cases were followed up without additional surgery, and no metastasis or recurrence was detected during the median follow-up period of 67.5 months.
conclusionsThis study showed an excellent long-term prognosis following ER of patients with rectal NETs, confirming that ER is a valid treatment option for small rectal NETs. The present study also revealed highly prevalent lymphovascular invasion even in minute rectal NETs; this observation raises a question regarding its significance as a risk factor for metastasis.
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