Evidence map›Paper›PMID 25935929›Full record

SynthesisSexually transmitted infections2016

Prevention of mother-to-child HIV transmission cascade in China: a systematic review and meta-analysis.

Huan Zeng, Eric P F Chow, Yong Zhao, Yang Wang, Maozhi Tang, Leyu Li, Xue Tang, Xi Liu, Yi Zhong, Ailing Wang and 2 more

Open access · hybridAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Sexually transmitted infections, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 6 pooled it
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 6 syntheses or guidelines pooled it, 40 citations in OpenAlex.

  1. Pooled it
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  7. Article
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  12. Observational
  13. Article
  14. Review
  15. Article
  16. History of the HIV Epidemic in China.Current HIV/AIDS reports · 2019
    Review
  17. Article
  18. Article
  19. Article
  20. International journal of pediatrics & adolescent medicine · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 6 institutions in 3 countries.

Huan ZengSchool of Public Health and Management, Chongqing Medical University, Chongqing, China China Effective Health Care Network, Chongqing, China Research Center for Medicine and Social Development, Chongqing Medical University, Chongqing, China The Innovation Center for Social Risk Governance in Health, Chongqing Medical University, Chongqing, China.
Eric P F ChowThe Kirby Institute, University of New South Wales, Sydney, New South Wales, Australia Faculty of Medicine, Nursing and Health Sciences, Central Clinical School, Monash University, Melbourne, Australia Melbourne Sexual Health Centre, Alfred Health, Melbourne, Australia.
Yong ZhaoSchool of Public Health and Management, Chongqing Medical University, Chongqing, China China Effective Health Care Network, Chongqing, China Research Center for Medicine and Social Development, Chongqing Medical University, Chongqing, China The Innovation Center for Social Risk Governance in Health, Chongqing Medical University, Chongqing, China.
Yang WangSchool of Public Health and Management, Chongqing Medical University, Chongqing, China China Effective Health Care Network, Chongqing, China Research Center for Medicine and Social Development, Chongqing Medical University, Chongqing, China The Innovation Center for Social Risk Governance in Health, Chongqing Medical University, Chongqing, China.
Maozhi TangSchool of Pediatrics, Chongqing Medical University, Chongqing, China.
Leyu LiSchool of Pediatrics, Chongqing Medical University, Chongqing, China.
Xue TangSchool of Pediatrics, Chongqing Medical University, Chongqing, China.
Xi LiuSchool of Pediatrics, Chongqing Medical University, Chongqing, China.
Yi ZhongSchool of Pediatrics, Chongqing Medical University, Chongqing, China.
Ailing WangWomen's Health Department, National Center for Women's and Children's Health, China CDC, Beijing, China.
Ying-Ru LoDepartment of HIV&STI, WHO Regional Office for the Western Pacific, Manila, The Philippines.
Lei ZhangFaculty of Medicine, Nursing and Health Sciences, Central Clinical School, Monash University, Melbourne, Australia Melbourne Sexual Health Centre, Alfred Health, Melbourne, Australia School of Medicine, Research Center for Public Health, Tsinghua University, Beijing, China.
Chongqing Medical University · CNChongqing Public Health Medical Center · CNMelbourne Sexual Health Centre · AUNational Center for Women and Children’s Health, China CDC · CNTsinghua University · CNWorld Health Organization Regional Office for the Western Pacific · PH

Funding

World Health Organization 001
6 · The paper itself

Abstract

introductionThe Chinese government has invested US$140 million annually on prevention of mother-to-child transmission (PMTCT) of HIV. This study evaluates the programme by examining the improvements in programme coverage HIV testing and provision of antiviral drugs along the PMTCT cascade.

methodsData for PMTCT cascade indicators were collected through a comprehensive systematic review of published peer-reviewed English and Chinese literature during 2003-2011. Meta-analysis was conducted according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines.

resultsThis study included 113 publications. HIV prevalence among pregnant women in China who accessed antenatal care (ANC) remained below 0.1% during the past decade. HIV testing coverage in pregnant women attending ANC and in HIV-exposed infants at 18 months significantly increased from 62.4% (95% CI 4.7% to 98.2%) and 22.1% (16.3% to 32.3%) in 2003 to 90.3% (88.4% to 91.8%) and 82.8% (66.9% to 99.5%) in 2011 respectively, whereas antiretroviral (ARV) prophylaxis uptake increased from 35.2% (12.2% to 47.3%) and 26.9% (24.3% to 28.9%) to 86.2% (53.2% to 97.2%) and 90.3% (85.5% to 93.7%). HIV vertical transmission rate substantially decreased from 31.8% (25.7% to 38.6%) prior to the programme to 2.3% (1.4% to 3.8%) in 2011. During 2003-2011, among 25,312 (23,995-26,644) infants born to HIV-positive mothers who received ARV prophylaxis, 975 (564-1395) were diagnosed with HIV, corresponding to an average transmission rate of 3.9% (3.2% to 4.6%). However, while including transmissions among HIV-positive pregnant women who were lost along the cascade, the average transmission rate during 2003-2011 was 17.4% (15.8% to 19.0%).

conclusionsPMTCT programmes have reduced HIV mother-to-child transmission in China. Further improvements in the continuum of care remain essential in realising the full potential of the programme.

Indexed as

AdultChinaFemaleHIV InfectionsHumansInfantInfant, NewbornInfectious Disease Transmission, VerticalMaleMothersPregnancyPregnancy Complications, InfectiousPrenatal CareAIDSANTIRETROVIRAL THERAPYHIVWOMEN

Identifiers

PMID25935929
PMCPMC4783331
OpenAlexW2001536055

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.