ArticleBMJ case reports2015
Gallbladder perforation and massive intra-abdominal haemorrhage complicating acute cholecystitis in a patient with haemophilia A.
Article in BMJ case reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 9 citations in OpenAlex.
- Haemorrhagic cholecystitis in a young patient, complicated by gallbladder perforation and choledocholithiasis.BMJ case reports · 2023Article
- Perforated hemorrhagic cholecystitis in a patient with Bernard-Soulier syndrome.Clinical journal of gastroenterology · 2022Article
- Hemorrhagic cholecystitis with auto-avulsion.Radiology case reports · 2021Article
- Hemorrhagic cholecystitis: ultrasound and CT imaging findings-a retrospective case review series.Emergency radiology · 2021Article
- Acute hemorrhagic cholecystitis with gallbladder rupture and massive intra-abdominal hemorrhage.Autopsy & case reports · 2021Article
- Gallbladder perforation without cholecystitis in a patient awaiting liver transplantation: a peculiar case report of anaemia in cirrhosis.BMC gastroenterology · 2019Article
- Acute cholecystitis and gallbladder perforation leading to massive haemoperitoneum in a patient taking rivaroxaban.BMJ case reports · 2018Article
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We present an unusual case of a 32-year-old man with haemophilia A, who sustained massive, haemodynamically significant intra-abdominal bleeding from a perforated gallbladder wall and from the greater omentum as a complication of acute ulcerophlegmonous and haemorrhagic cholecystitis. Recombinant coagulation factor VIII was given and an emergency laparotomy was performed, with open cholecystectomy and haemostasis. Coagulation factor VIII was given for a further 2 weeks postoperatively, and the patient was discharged in good condition. In most published cases of haemorrhagic cholecystitis, the haemoperitoneum arises via transhepatic perforation; in this case, there was a free rupture into the peritoneal cavity. Patients with coagulopathies may have severe haemorrhagic complications and therefore need interdisciplinary management before, during and after surgery. Replacement therapy with factor concentrates should be initiated at once, and early surgery for gallbladder disease should be considered.
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