Evidence map›Paper›PMID 25935868›Full record

ArticleCardiovascular research2015

Synchronization of repolarization by mechano-electrical coupling in the porcine heart.

Tobias Opthof, Veronique M F Meijborg, Charly N W Belterman, Ruben Coronel

Abstract read
PubMed Publisher
In one paragraph

Article in Cardiovascular research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Emerging evidence for a mechanistic link between low-frequency oscillation of ventricular repolarization measured from the electrocardiogram T-wave vector and arrhythmia.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2021
    Review
  3. Article
  4. Article
  5. Rabbit models of cardiac mechano-electric and mechano-mechanical coupling.Progress in biophysics and molecular biology · 2016
    Review
  6. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors.

Tobias OpthofExperimental Cardiology Group, Department of Clinical and Experimental Cardiology, Academic Medical Centre, Room K2-112, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands Department of Medical Physiology, University Medical Center Utrecht, Utrecht, The Netherlands.
Veronique M F MeijborgExperimental Cardiology Group, Department of Clinical and Experimental Cardiology, Academic Medical Centre, Room K2-112, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands.
Charly N W BeltermanExperimental Cardiology Group, Department of Clinical and Experimental Cardiology, Academic Medical Centre, Room K2-112, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands University Bordeaux Segalen, L'Institut de RYthmologie et modélisation Cardiaque (LIRYC), Bordeaux, France.
Ruben CoronelExperimental Cardiology Group, Department of Clinical and Experimental Cardiology, Academic Medical Centre, Room K2-112, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands University Bordeaux Segalen, L'Institut de RYthmologie et modélisation Cardiaque (LIRYC), Bordeaux, France rubencoronel@gmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimsThe aim of this study was to evaluate the effect of increase in left ventricular (LV) pressure on repolarization and activation-recovery intervals. METHODS AND

resultsSix pig hearts were Langendorff-perfused. A compliant liquid-filled balloon, connected with a pressure transducer, inserted through the mitral orifice, could be filled until the required LV systolic pressure was obtained. A grid of 121 electrodes (11 × 11; 5 mm interelectrode distance) was sutured on the LV free wall. Ventricular pacing at 600 ms and at 400 or 450 ms was either performed from the LV wall or from the ventricular septum. Under all these four conditions, the pressure wave occurred at the same moment relative to the onset of the QRS complex. Consequently, the time relation between local repolarization and the pressure wave differed between the various pacing sites. Repolarization times (RTs) at a cycle length (CL) of 600 ms were prolonged by increased pressure. With stimulation from the LV, when the pressure wave coincides with the action potentials (APs) late in their phase (sites with relatively early repolarization), an increase in pressure from 0 to 100 mmHg delayed repolarization more than with stimulation from the septum, when the pressure wave occurs at a relatively earlier phase of the AP (sites with relatively late repolarization). At pacing at CL 400/450 ms, an increase in pressure caused RT prolongation at the LV free wall during LV stimulation, but less RT prolongation or even shortening during septal stimulation.

conclusionThe effect of increased LV pressure is synchronization of repolarization.

Indexed as

Action PotentialsAnimalsBlood PressureCardiac Pacing, ArtificialElectrocardiographyHeartMaleSwineVentricular Function, LeftActivation-recovery intervalDispersion in repolarizationMechano-electrical couplingPig heartRepolarization

Identifiers

PMID25935868

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.