ReviewEndocrine pathology2015
Breast metastasis as the first clinical manifestation of ileal neuroendocrine tumor. A challenging diagnosis with relevant clinical implications.
Review in Endocrine pathology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 14 citations in OpenAlex.
- Neuroendocrine Tumor Metastases to the Breast Mimic Breast Primary Carcinoma: Mammography and Multimodality US Assessment in Challenging Differential Diagnosis.Diagnostics (Basel, Switzerland) · 2025Article
- Neuroendocrine Tumor Metastases to the Breast: A Case Report and Review of the Literature.Cureus · 2023Article
- Bilateral breast metastases as the first manifestation of an occult pancreatic neuroendocrine tumor.Radiology case reports · 2021Article
- On the Endless Dilemma of Neuroendocrine Neoplasms of the Breast: a Journey Through Concepts and Entities.Endocrine pathology · 2020Review
- The rare entity of bilateral and unilateral neuroendocrine metastases to the breast: a case series and literature review.Ecancermedicalscience · 2020Article
- Article
- Occult Primary Neuroendocrine Tumor Metastasis to the Breast Detected on Screening Mammogram.Journal of clinical imaging science · 2016Article
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ileal neuroendocrine tumors are slow-growing grade 1 or, more rarely, grade 2 neuroendocrine tumors which, however, are frequently metastatic to regional lymph nodes and the liver. A few cases of ileal neuroendocrine tumors that are metastatic to the breast have also been reported in the medical literature. The knowledge of this uncommon clinical presentation is of great importance because it needs to be differentiated from primary breast carcinomas with neuroendocrine features, which represent completely different entities with a different therapeutic approach. The diagnosis of a breast metastasis from an ileal neuroendocrine tumor and its distinction from a well-differentiated primary neuroendocrine tumor of the breast is a challenging task for clinicians and pathologists. This workup is particularly difficult when the breast lesion is the first sign of malignancy. In the present paper, we describe the clinicopathological features of an ileal neuroendocrine tumor first presenting with a breast metastasis in a 50-year-old woman and we discuss the key diagnostic features for the differential diagnosis with primary well-differentiated neuroendocrine tumor of the breast. Moreover, we have reviewed the medical literature to give the reader a comprehensive overview on this topic.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.