ArticleArchives of biochemistry and biophysics2015
SR-135, a peroxynitrite decomposing catalyst, enhances β-cell function and survival in B6D2F1 mice fed a high fat diet.
Article in Archives of biochemistry and biophysics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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4 citing papers in PubMed, 8 citations in OpenAlex.
- Consequences of Disturbing Manganese Homeostasis.International journal of molecular sciences · 2023Review
- Study of blood glucose and insulin infusion rate in real-time in diabetic rats using an artificial pancreas system.PloS one · 2021Article
- Tracking changes of the parameters of glucose-insulin homeostasis during the course of obesity in B6D2F1 mice.Heliyon · 2020Article
- The Essential Element Manganese, Oxidative Stress, and Metabolic Diseases: Links and Interactions.Oxidative medicine and cellular longevity · 2018Review
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Authors and funding
12 authors at 1 institution in 1 country.
Funding
Abstract
Peroxynitrite has been implicated in β-cell dysfunction and insulin resistance in obesity. Chemical catalysts that destroy peroxynitrite, therefore, may have therapeutic value for treating type 2 diabetes. To this end, we have recently demonstrated that Mn(III) bis(hydroxyphenyl)-dipyrromethene complexes, SR-135 and its analogs, can effectively catalyze the decomposition of peroxynitrite in vitro and in vivo through a 2-electron mechanism (Rausaria et al., 2011). To study the effects of SR-135 on glucose homeostasis in obesity, B6D2F1 mice were fed with a high fat-diet (HFD) for 12 weeks and treated with vehicle, SR-135 (5mg/kg), or a control drug SRB for 2 weeks. SR-135 significantly reduced fasting blood glucose and insulin levels, and enhanced glucose tolerance as compared to HFD control, vehicle or SRB. SR-135 also enhanced glucose-stimulated insulin secretion based on ex vivo studies. Moreover, SR-135 increased insulin content, restored islet architecture, decreased islet size, and reduced tyrosine nitration and apoptosis. These results suggest that a peroxynitrite decomposing catalyst enhances β-cell function and survival under nutrient overload.
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