Evidence map›Paper›PMID 25935330›Full record

ArticleWorld journal of urology2015

An antimicrobial prophylaxis protocol using rectal swab cultures for transrectal prostate biopsy.

Stephen J Summers, Darshan P Patel, Blake D Hamilton, Angela P Presson, Mark A Fisher, William T Lowrance, Andrew W Southwick

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Article in World journal of urology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
5.0field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Stephen J SummersDivision of Urology, Department of Surgery, University of Utah Health Care, University of Utah, 30 N 1900 E, RM 3B420, Salt Lake City, UT, 84132, USA.
Darshan P PatelDivision of Urology, Department of Surgery, University of Utah Health Care, University of Utah, 30 N 1900 E, RM 3B420, Salt Lake City, UT, 84132, USA.
Blake D HamiltonDivision of Urology, Department of Surgery, University of Utah Health Care, University of Utah, 30 N 1900 E, RM 3B420, Salt Lake City, UT, 84132, USA.
Angela P PressonDivision of Epidemiology, University of Utah, Salt Lake City, UT, USA.
Mark A FisherDepartment of Pathology, University of Utah, Salt Lake City, UT, USA.
William T LowranceDivision of Urology, Department of Surgery, University of Utah Health Care, University of Utah, 30 N 1900 E, RM 3B420, Salt Lake City, UT, 84132, USA.
Andrew W SouthwickDivision of Urology, Department of Surgery, University of Utah Health Care, University of Utah, 30 N 1900 E, RM 3B420, Salt Lake City, UT, 84132, USA. Andrew.southwick@hsc.utah.edu.
University of Utah · USGeorge E. Wahlen Department of VA Medical Center · USARUP Laboratories (United States) · USUniversity of Utah Health Care · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo evaluate the benefit of an antimicrobial prophylaxis protocol using rectal swab cultures in patients undergoing transrectal ultrasound (TRUS)-guided prostate biopsy in our Veterans Affairs population.

methodsBetween June 1, 2013, and June 1, 2014, we implemented an antimicrobial prophylaxis protocol using rectal swab cultures on selective media containing ciprofloxacin for all men scheduled for TRUS-guided prostate biopsy. Data from 2759 patients from Jan 1, 2006 to May 31, 2013, before protocol implementation served as historical controls. Patients with fluoroquinolone (FQ)-susceptible organisms received FQ monotherapy, while those with FQ-resistant organisms received targeted prophylaxis. Our objective was to compare the rate of infectious complications 30 days after prostate biopsy before and after implementation of our antimicrobial protocol.

resultsOne hundred and sixty-seven patients received rectal swab cultures using our protocol. Seventeen (14 %) patients had FQ-resistant positive cultures. Patients with positive FQ-resistant culture results were more likely to have had a history of previous prostate biopsy and a positive urine culture in the last 12 months (p = 0.032, p = 0.018, respectively). The average annual infectious complication rate within 30 days of biopsy was reduced from 2.8 to 0.6 % before and after implementation of our antimicrobial prophylaxis protocol using rectal swab cultures, although this difference was not statistically significant (p = 0.13).

conclusionAn antimicrobial prophylaxis protocol using rectal culture swabs is a viable option for prevention of TRUS-guided prostate biopsy infectious complications. After implementation of an antimicrobial prophylaxis protocol, we observed a nonsignificant decrease in the rate of post-biopsy infectious complications when compared to historical controls.

Indexed as

Antibiotic ProphylaxisImage-Guided BiopsyUltrasonography, InterventionalAgedClinical ProtocolsHumansMaleMiddle AgedProspective StudiesProstatic NeoplasmsRectumTreatment OutcomeAntibiotic prophylaxis/methodsBiopsy/methodsPostoperative complications/prevention and controlProstate/pathologyProstate/ultrasonographyRectum/microbiology

Identifiers

PMID25935330
OpenAlexW1974270008

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.