ArticleThe Journal of allergy and clinical immunology2015
Patterns of IgE responses to multiple allergen components and clinical symptoms at age 11 years.
Article in The Journal of allergy and clinical immunology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
30 citing papers in PubMed, 82 citations in OpenAlex.
- Features of asthma which provide meaningful insights for understanding the disease heterogeneity.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2018Trial
- Novel, computational IgE-clustering in a population-based cross-sectional study: Mapping the allergy burden.Clinical and translational allergy · 2023Article
- Associations of Four sensitization patterns revealed by Latent Class Analysis with Clinical symptoms: A multi-center study of China.EClinicalMedicine · 2022Article
- Development of Sensitization to Multiple Allergen Molecules from Preschool to School Age Is Related to Asthma.International archives of allergy and immunology · 2022Article
- Classification of patients with esophageal eosinophilia by patterns of sensitization revealed by a diagnostic assay for multiple allergen-specific IgEs.Journal of gastroenterology · 2021Observational
- The Molecular Allergen Recognition Profile in China as Basis for Allergen-Specific Immunotherapy.Frontiers in immunology · 2021Review
- Linking cross-reactivity clusters of food and respiratory allergens in PAMD@ to asthma and duration of allergy.The World Allergy Organization journal · 2020Article
- IgE responses to multiple allergen components among school-aged children in a general population birth cohort in Tokyo.The World Allergy Organization journal · 2020Article
- A WAO - ARIA - GAThe World Allergy Organization journal · 2020Article
- Allergic Endotypes and Phenotypes of Asthma.The journal of allergy and clinical immunology. In practice · 2020Article
- Asthma and allergic rhinitis risk depends on house dust mite specific IgE levels in PARIS birth cohort children.The World Allergy Organization journal · 2019Article
- Pediatric asthma: An unmet need for more effective, focused treatments.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2019Review
- Article
- Epidemiology of Asthma in Children and Adults.Frontiers in pediatrics · 2019Review
- Blood Biomarkers of Sensitization and Asthma.Frontiers in pediatrics · 2019Review
- Article
- Evolution of IgE responses to multiple allergen components throughout childhood.The Journal of allergy and clinical immunology · 2018Article
- International Consensus Statement on Allergy and Rhinology: Allergic Rhinitis.International forum of allergy & rhinology · 2018Article
- Lipid-Reactive T Cells in Immunological Disorders of the Lung.Frontiers in immunology · 2018Review
- Classification of Pediatric Asthma: From Phenotype Discovery to Clinical Practice.Frontiers in pediatrics · 2018Review
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundThe relationship between sensitization to allergens and disease is complex.
objectiveWe sought to identify patterns of response to a broad range of allergen components and investigate associations with asthma, eczema, and hay fever.
methodsSerum specific IgE levels to 112 allergen components were measured by using a multiplex array (Immuno Solid-phase Allergen Chip) in a population-based birth cohort. Latent variable modeling was used to identify underlying patterns of component-specific IgE responses; these patterns were then related to asthma, eczema, and hay fever.
resultsTwo hundred twenty-one of 461 children had IgE to 1 or more components. Seventy-one of the 112 components were recognized by 3 or more children. By using latent variable modeling, 61 allergen components clustered into 3 component groups (CG1, CG2, and CG3); protein families within each CG were exclusive to that group. CG1 comprised 27 components from 8 plant protein families. CG2 comprised 7 components of mite allergens from 3 protein families. CG3 included 27 components of plant, animal, and fungal origin from 12 protein families. Each CG included components from different biological sources with structural homology and also nonhomologous proteins arising from the same biological source. Sensitization to CG3 was most strongly associated with asthma (odds ratio [OR], 8.20; 95% CI, 3.49-19.24; P < .001) and lower FEV1 (P < .001). Sensitization to CG1 was associated with hay fever (OR, 12.79; 95% CI, 6.84-23.90; P < .001). Sensitization to CG2 was associated with both asthma (OR, 3.60; 95% CI, 2.05-6.29) and hay fever (OR, 2.52; 95% CI, 1.38-4.61).
conclusionsLatent variable modeling with a large number of allergen components identified 3 patterns of IgE responses, each including different protein families. In 11-year-old children the pattern of response to components of multiple allergens appeared to be associated with current asthma and hay fever but not eczema.
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Registered trials
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