Evidence map›Paper›PMID 25935004›Full record

ArticleHuman molecular genetics2015

Epigenome-wide association study (EWAS) of BMI, BMI change and waist circumference in African American adults identifies multiple replicated loci.

Ellen W Demerath, Weihua Guan, Megan L Grove, Stella Aslibekyan, Michael Mendelson, Yi-Hui Zhou, Åsa K Hedman, Johanna K Sandling, Li-An Li, Marguerite R Irvin and 14 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Human molecular genetics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 226 papers, 21 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
226citing papers in PubMed, 21 pooled it
19.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

226 citing papers in PubMed, 21 syntheses or guidelines pooled it, 385 citations in OpenAlex.

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166 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors at 12 institutions in 4 countries.

Ellen W DemerathDivision of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, MN 55454, USA, ewd@umn.edu.
Weihua GuanDivision of Biostatistics, School of Public Health, University of Minnesota, Minneapolis, MN 55454, USA.
Megan L GroveHuman Genetics Center, School of Public Health, University of Texas Health Sciences Center at Houston, Houston, TX 77030, USA.
Stella AslibekyanDepartment of Epidemiology and.
Michael MendelsonPopulation Sciences Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20824, USA, Framingham Heart Study, Framingham, MA 01702, USA, Department of Cardiology, Boston Children's Hospital, Boston, MA 02215, USA.
Yi-Hui ZhouDepartment of Statistics, North Carolina State University, Raleigh, NC 27695, USA.
Åsa K HedmanWellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK, Department of Medical Sciences, Molecular Medicine and Science for Life Laboratory, Uppsala University, Uppsala, Sweden.
Johanna K SandlingDepartment of Medical Sciences, Molecular Medicine and Science for Life Laboratory, Uppsala University, Uppsala, Sweden, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, UK.
Li-An LiHuman Genome Sequencing Center, Baylor College of Medicine, Houston, TX 77030, USA.
Marguerite R IrvinDepartment of Epidemiology and.
Degui ZhiDepartment of Biostatistics, School of Public Health, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Panos DeloukasWellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, UK, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK, Princess Al-Jawhara Al-Brahim Centre of Excellence in Research of Hereditary Disorders (PACER-HD), King Abdulaziz University, Jeddah 21589, Saudi Arabia.
Liming LiangPopulation Sciences Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20824, USA, Framingham Heart Study, Framingham, MA 01702, USA, Departments of Epidemiology and Biostatistics, School of Public Health, Harvard University, Boston, MA 02115, USA.
Chunyu LiuFramingham Heart Study, Framingham, MA 01702, USA, Department of Biostatistics, Boston University, Boston, MA 02118, USA.
Jan BresslerHuman Genetics Center, School of Public Health, University of Texas Health Sciences Center at Houston, Houston, TX 77030, USA.
Tim D SpectorDepartment of Twin Research and Genetic Epidemiology, King's College London, London SE1 7EH, UK.
Kari NorthDepartment of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27514, USA.
Yun LiDepartment of Genetics, Department of Biostatistics and Department of Computer Science, University of North Carolina, Chapel Hill, NC 27599, USA.
Devin M AbsherHudson Alpha Institute for Biotechnology, Huntsville, AL 34806, USA.
Daniel LevyPopulation Sciences Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20824, USA, Framingham Heart Study, Framingham, MA 01702, USA.
Donna K ArnettDepartment of Epidemiology and.
Myriam FornageHuman Genetics Center, School of Public Health, University of Texas Health Sciences Center at Houston, Houston, TX 77030, USA, Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX 77030, USA.
James S PankowDivision of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, MN 55454, USA.
Eric BoerwinkleHuman Genetics Center, School of Public Health, University of Texas Health Sciences Center at Houston, Houston, TX 77030, USA, Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX 77030, USA.
The University of Texas Health Science Center at Houston · USUniversity of Minnesota · USBaylor College of Medicine · USFramingham Heart Study · USNational Institutes of Health · USUniversity of North Carolina at Chapel Hill · USWellcome Sanger Institute · GBHudsonAlpha Institute for Biotechnology · USKing's College London · GBNorth Carolina State University · USUniversity of Alabama at Birmingham · USUppsala University · SE

Funding

Framingham Project/LevyZIAHL006001 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI LEVY, DANIEL · 2009 to 2025
$51.1M
Building on GWAS for NHLBI-disease: the CHARGE consortiumRC2HL102419 · NHLBI · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI BOERWINKLE, ERIC A. · 2009 to 2010
$27.6M
Genetic and Environmental Determinants of TriglyceridesU01HL072524 · NHLBI · UNIVERSITY OF MINNESOTA TWIN CITIES · PI ARNETT, DONNA K · 2002 to 2008
$11.9M
Epigenetic Determinants of Lipid Response to Dietary Fat and FenofibrateR01HL104135 · NHLBI · UNIVERSITY OF KENTUCKY · PI ARNETT, DONNA K · 2010 to 2015
$5.5M
THE FRAMINGHAM HEART STUDY-N01HC25195-268025195-268025195N01HC025195 · HC · TRUSTEES OF BOSTON UNIVERSITY · PI WOLF, PHILIP A · 2002 to 2006
–
Department of HealthIntramural NIH HHSNHLBI NIH HHS 5RC2HL102419NHLBI NIH HHS N01-HC-25195NHLBI NIH HHS R01 HL104135NHLBI NIH HHS U01 HL072524NHLBI NIH HHS U01HL072524-04PHS HHS HHSN268201100005CPHS HHS HHSN268201100006CPHS HHS HHSN268201100007CPHS HHS HHSN268201100008CPHS HHS HHSN268201100009CPHS HHS HHSN268201100010CPHS HHS HHSN268201100011CPHS HHS HHSN268201100012CWellcome Trust
6 · The paper itself

Abstract

Obesity is an important component of the pathophysiology of chronic diseases. Identifying epigenetic modifications associated with elevated adiposity, including DNA methylation variation, may point to genomic pathways that are dysregulated in numerous conditions. The Illumina 450K Bead Chip array was used to assay DNA methylation in leukocyte DNA obtained from 2097 African American adults in the Atherosclerosis Risk in Communities (ARIC) study. Mixed-effects regression models were used to test the association of methylation beta value with concurrent body mass index (BMI) and waist circumference (WC), and BMI change, adjusting for batch effects and potential confounders. Replication using whole-blood DNA from 2377 White adults in the Framingham Heart Study and CD4+ T cell DNA from 991 Whites in the Genetics of Lipid Lowering Drugs and Diet Network Study was followed by testing using adipose tissue DNA from 648 women in the Multiple Tissue Human Expression Resource cohort. Seventy-six BMI-related probes, 164 WC-related probes and 8 BMI change-related probes passed the threshold for significance in ARIC (P < 1 × 10(-7); Bonferroni), including probes in the recently reported HIF3A, CPT1A and ABCG1 regions. Replication using blood DNA was achieved for 37 BMI probes and 1 additional WC probe. Sixteen of these also replicated in adipose tissue, including 15 novel methylation findings near genes involved in lipid metabolism, immune response/cytokine signaling and other diverse pathways, including LGALS3BP, KDM2B, PBX1 and BBS2, among others. Adiposity traits are associated with DNA methylation at numerous CpG sites that replicate across studies despite variation in tissue type, ethnicity and analytic approaches.

Indexed as

AgedAtherosclerosisBlack or African AmericanBody Mass IndexDNA MethylationEpigenesis, GeneticFemaleGenome-Wide Association StudyHumansLipid MetabolismMaleMetabolic Networks and PathwaysMiddle AgedObesityWaist CircumferenceWhite People

Identifiers

PMID25935004
PMCPMC4492394
OpenAlexW2116790770

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.