SynthesisNeurology2015
Shared genetic basis for migraine and ischemic stroke: A genome-wide analysis of common variants.
Abstract readMeta-Analysis
In one paragraph
Synthesis in Neurology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers, 4 of them syntheses that pooled it.
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54citing papers in PubMed, 4 pooled it
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Who cites it
54 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Cross-trait analyses identify shared genetics between migraine, headache, and glycemic traits, and a causal relationship with fasting proinsulin.Human genetics · 2023Pooled it
- Myocardial infarction, stroke and cardiovascular mortality among migraine patients: a systematic review and meta-analysis.Journal of neurology · 2022Pooled it
- Genome-wide analysis of 102,084 migraine cases identifies 123 risk loci and subtype-specific risk alleles.Nature genetics · 2022Pooled it
- Meta-analysis of 375,000 individuals identifies 38 susceptibility loci for migraine.Nature genetics · 2016Pooled it
- Migraines and the association of cognitive impairment: a one- and two-sample mendelian randomization analysis.Dialogues in clinical neuroscience · 2026Article
- Exploring Vascular Contributions to Migraine: Association Analysis of Small Vessel Disease Genetic Variants.Genes · 2026Article
- Identification of common genetic and molecular signatures in migraine and comorbid conditions.The journal of headache and pain · 2026Review
- Ischaemic stroke in young adults: an overview of the classification, risk factors, aetiologies and outcomes.Singapore medical journal · 2026Review
- Exploring Contraindicated Medications and Corresponding Targeted Genes for Migraine Through Integrated Genetic Approaches.Brain and behavior · 2025Article
- From Headache to Heart Health: Investigating the Migraine-Cardiovascular Disease Connection.Neurology and therapy · 2025Review
- PRDM16, a new kid on the block in cardiovascular health and disease.Cardiovascular research · 2025Review
- Article
- Sirtuins Contribute to the Migraine-Stroke Connection.International journal of molecular sciences · 2025Review
- Migraine with and without aura-two distinct entities? A narrative review.The journal of headache and pain · 2025Review
- Migraine and stroke: correlation, coexistence, dependence - a modern perspective.The journal of headache and pain · 2025Review
- Hallmarks of primary headache: part 1 - migraine.The journal of headache and pain · 2024Review
- Prediagnosis recognition of acute ischemic stroke by artificial intelligence from facial images.Aging cell · 2024Article
- Association between vertebral artery dominance and basilar artery curvature in migraineurs: an anatomical magnetic resonance imaging study.The neuroradiology journal · 2024Article
- Genetic causal relationship between immune diseases and migraine: a Mendelian randomization study.Frontiers in immunology · 2024Article
- Reviewing migraine-associated pathophysiology and its impact on elevated stroke risk.Frontiers in neurology · 2024Review
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Authors and funding
55 authors.
Rainer MalikAuthor affiliations are provided at the end of the article.
Tobias FreilingerAuthor affiliations are provided at the end of the article.
Bendik S WinsvoldAuthor affiliations are provided at the end of the article.
Verneri AnttilaAuthor affiliations are provided at the end of the article.
Jason Vander HeidenAuthor affiliations are provided at the end of the article.
Matthew TraylorAuthor affiliations are provided at the end of the article.
Boukje de VriesAuthor affiliations are provided at the end of the article.
Elizabeth G HollidayAuthor affiliations are provided at the end of the article.
Gisela M TerwindtAuthor affiliations are provided at the end of the article.
Jonathan SturmAuthor affiliations are provided at the end of the article.
Joshua C BisAuthor affiliations are provided at the end of the article.
Jemma C HopewellAuthor affiliations are provided at the end of the article.
Michel D FerrariAuthor affiliations are provided at the end of the article.
Kristiina RannikmaeAuthor affiliations are provided at the end of the article.
Maija WessmanAuthor affiliations are provided at the end of the article.
Mikko KallelaAuthor affiliations are provided at the end of the article.
Christian KubischAuthor affiliations are provided at the end of the article.
Myriam FornageAuthor affiliations are provided at the end of the article.
James F MeschiaAuthor affiliations are provided at the end of the article.
Terho LehtimäkiAuthor affiliations are provided at the end of the article.
Cathie SudlowAuthor affiliations are provided at the end of the article.
Robert ClarkeAuthor affiliations are provided at the end of the article.
Daniel I ChasmanAuthor affiliations are provided at the end of the article.
Braxton D MitchellAuthor affiliations are provided at the end of the article.
Jane MaguireAuthor affiliations are provided at the end of the article.
Jaakko KaprioAuthor affiliations are provided at the end of the article.
Martin FarrallAuthor affiliations are provided at the end of the article.
Olli T RaitakariAuthor affiliations are provided at the end of the article.
Tobias KurthAuthor affiliations are provided at the end of the article.
M Arfan IkramAuthor affiliations are provided at the end of the article.
Alex P ReinerAuthor affiliations are provided at the end of the article.
W T LongstrethAuthor affiliations are provided at the end of the article.
Peter M RothwellAuthor affiliations are provided at the end of the article.
David P StrachanAuthor affiliations are provided at the end of the article.
Pankaj SharmaAuthor affiliations are provided at the end of the article.
Sudha SeshadriAuthor affiliations are provided at the end of the article.
Lydia QuayeAuthor affiliations are provided at the end of the article.
Lynn CherkasAuthor affiliations are provided at the end of the article.
Markus SchürksAuthor affiliations are provided at the end of the article.
Jonathan RosandAuthor affiliations are provided at the end of the article.
Lannie LigthartAuthor affiliations are provided at the end of the article.
Giorgio B BoncoraglioAuthor affiliations are provided at the end of the article.
George Davey SmithAuthor affiliations are provided at the end of the article.
Cornelia M van DuijnAuthor affiliations are provided at the end of the article.
Kari StefanssonAuthor affiliations are provided at the end of the article.
Bradford B WorrallAuthor affiliations are provided at the end of the article.
Dale R NyholtAuthor affiliations are provided at the end of the article.
Hugh S MarkusAuthor affiliations are provided at the end of the article.
Arn M J M van den MaagdenbergAuthor affiliations are provided at the end of the article.
Chris CotsapasAuthor affiliations are provided at the end of the article.
John A ZwartAuthor affiliations are provided at the end of the article.
Aarno PalotieAuthor affiliations are provided at the end of the article.
International Headache Genetics Consortium
Martin DichgansAuthor affiliations are provided at the end of the article. martin.dichgans@med.uni-muenchen.de.
METASTROKE Collaboration of the International Stroke Genetics Consortium
Funding
Institute for Clinical and Translational Research (UL1)UL1RR025005 · NCRR · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2007 to 2011
$75.8MType 1 Diabetes Genetics ConsortiumU01DK062418 · NIDDK · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI RICH, STEPHEN S. · 2002 to 2007
$59.8MUCLA Clinical and Translational Science InstituteUL1TR000124 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DUBINETT, STEVEN M. · 2012 to 2015
$57.0MTransgenic & Knock-out MouseP30DK063491 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Andrea L Hevener · 2003 to 2026
$40.4MUC Davis Alzheimer's Disease Core CenterP30AG010129 · NIA · UNIVERSITY OF CALIFORNIA DAVIS · PI MEYER, OANH L · 1991 to 2020
$28.3MWomen's Health Study: Continued Follow-upR01CA047988 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI BURING, JULIE E., LEE, I-MIN · 1991 to 2014
$28.2MPRECURSORS OF STROKE INCIDENCE AND PROGNOSISR01NS017950 · NINDS · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI Hugo Javier Aparicio, Jose Rafael Romero · 1985 to 2026
$22.9MGenome-Wide Association Analysis in Essential Hypertension (FEHGAS study)R01HL086694 · NHLBI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI ARAVINDA CHAKRAVARTI · 2007 to 2026
$21.2MResearch BaseP30DK072488 · NIDDK · UNIVERSITY OF MARYLAND BALTIMORE · PI MITCHELL, BRAXTON D, TAYLOR, SIMEON I. · 2005 to 2019
$17.3MUCLA CLINICAL AND TRANSLATIONAL SCIENCE INSTITUTEUL1RR033176 · NCRR · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DUBINETT, STEVEN M. · 2011 to 2011
$15.5MEPIDEMIOLOGY OF DEMENTIA IN THE FRAMINGHAM STUDYR01AG008122 · NIA · BOSTON UNIVERSITY MEDICAL CAMPUS · PI AU, RHODA, SESHADRI, SUDHA · 1989 to 2015
$14.4MAN NCRR CENTER FOR HIGH THROUGHPUT SNP GENOTYPING AND ANALYSIS: GAIN NETWORKU54RR020278 · NCRR · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI GABRIEL, STACEY · 2004 to 2008
$14.4MBritish Heart Foundation FS/14/55/30806Medical Research Council 0600331Medical Research Council G0000934Medical Research Council G0500539Medical Research Council G0600331Medical Research Council G0600705Medical Research Council G1001799Medical Research Council MR/N01104X/1NCATS NIH HHS UL1 TR000124NCATS NIH HHS UL1TR000124NCI NIH HHS CA‐47988NCI NIH HHS UM1 CA182913NCRR NIH HHS U54 RR020278NCRR NIH HHS UL1 RR025005NCRR NIH HHS UL1RR025005NCRR NIH HHS UL1 RR033176NCRR NIH HHS UL1RR033176NHGRI NIH HHS U01 HG004402NHGRI NIH HHS U01 HG004436NHGRI NIH HHS U01HG004436NHGRI NIH HHS U01 HG 004446NHLBI NIH HHS 5R01HL087679‐02NHLBI NIH HHS HHSN268201100005CNHLBI NIH HHS HHSN268201100005GNHLBI NIH HHS HHSN268201100005INHLBI NIH HHS HHSN268201100006CNHLBI NIH HHS HHSN268201100007CNHLBI NIH HHS HHSN268201100007INHLBI NIH HHS HHSN268201100008CNHLBI NIH HHS HHSN268201100008INHLBI NIH HHS HHSN268201100009CNHLBI NIH HHS HHSN268201100009INHLBI NIH HHS HHSN268201100010CNHLBI NIH HHS HHSN268201100011CNHLBI NIH HHS HHSN268201100011INHLBI NIH HHS HHSN268201100012CNHLBI NIH HHS HHSN268201200036CNHLBI NIH HHS HL‐043851NHLBI NIH HHS HL080295NHLBI NIH HHS HL‐080467NHLBI NIH HHS HL087652NHLBI NIH HHS HL-093029NHLBI NIH HHS HL‐099355NHLBI NIH HHS HL105756NHLBI NIH HHS HL93029NHLBI NIH HHS N01 HC055015NHLBI NIH HHS N01 HC055016NHLBI NIH HHS N01 HC055018NHLBI NIH HHS N01 HC055019NHLBI NIH HHS N01 HC055020NHLBI NIH HHS N01 HC055021NHLBI NIH HHS N01 HC055022NHLBI NIH HHS N01 HC055222NHLBI NIH HHS N01 HC075150NHLBI NIH HHS N01 HC085079NHLBI NIH HHS N01 HC085080NHLBI NIH HHS N01 HC085081NHLBI NIH HHS N01 HC085082NHLBI NIH HHS N01 HC085083NHLBI NIH HHS N01 HC085084NHLBI NIH HHS N01 HC085085NHLBI NIH HHS N01 HC085086NHLBI NIH HHS R01 HL059367NHLBI NIH HHS R01 HL073410NHLBI NIH HHS R01 HL080295NHLBI NIH HHS R01 HL085251NHLBI NIH HHS R01 HL086694NHLBI NIH HHS R01HL086694NHLBI NIH HHS R01 HL087641NHLBI NIH HHS R01-HL087641NHLBI NIH HHS R01HL087641NHLBI NIH HHS R01 HL087652NHLBI NIH HHS R01 HL087676NHLBI NIH HHS R01 HL093029NHLBI NIH HHS R01-HL093029NHLBI NIH HHS R01 HL105756NHLBI NIH HHS R01HL59367NHLBI NIH HHS U01 HL080295NHLBI NIH HHS U01 HL096917NIAAA NIH HHS AA‐00145NIAAA NIH HHS AA07535NIAAA NIH HHS AA07728NIAAA NIH HHS AA‐09203NIAAA NIH HHS AA11998NIAAA NIH HHS AA‐12502NIAAA NIH HHS AA13320NIAAA NIH HHS AA13321NIAAA NIH HHS AA14041NIAAA NIH HHS AA15416NIAAA NIH HHS AA17688NIAAA NIH HHS K02 AA018755NIAAA NIH HHS K02AA018755NIAAA NIH HHS K05 AA017688NIAAA NIH HHS P50 AA011998NIAAA NIH HHS R01 AA007535NIAAA NIH HHS R01 AA007728NIAAA NIH HHS R01 AA013320NIAAA NIH HHS R01 AA013321NIAAA NIH HHS R01 AA014041NIAAA NIH HHS R01 AA015416NIAAA NIH HHS R37 AA007728NIA NIH HHS AG-023629NIA NIH HHS AG-027058NIA NIH HHS AG033193NIA NIH HHS AG-15928NIA NIH HHS AG-20098NIA NIH HHS P30 AG010129NIA NIH HHS R01 AG008122NIA NIH HHS R01 AG015928NIA NIH HHS R01 AG020098NIA NIH HHS R01 AG023629NIA NIH HHS R01 AG027058NIA NIH HHS R01 AG033193NIA NIH HHS R56 AG020098NIA NIH HHS R56 AG023629NIA NIH HHS Z01 AG-000015-50NIA NIH HHS Z01 AG-000954-06NIDA NIH HHS DA012854NIDA NIH HHS DA019951NIDA NIH HHS K08 DA019951NIDA NIH HHS R01 DA012854NIDA NIH HHS R56 DA012854NIDDK NIH HHS P30 DK063491NIDDK NIH HHS P30 DK072488NIDDK NIH HHS P30DK072488NIDDK NIH HHS U01 DK062418NIMH NIH HHS 1RL1MH083268‐01NIMH NIH HHS 5R01MH63706:02NIMH NIH HHS MH081802NIMH NIH HHS R01 MH081802NINDS NIH HHS NS‐061836NINDS NIH HHS NS17950NINDS NIH HHS R01 NS017950NINDS NIH HHS R01 NS039987NINDS NIH HHS R01 NS042733NINDS NIH HHS R01 NS045012NINDS NIH HHS R01 NS-39987NINDS NIH HHS R01 NS-42733NINDS NIH HHS R01 NS45012NINDS NIH HHS U01 NS069208NINDS NIH HHS U01NS069208-01PHS HHS R01D0042157‐01AThe Dunhill Medical Trust OSRP2/1006Wellcome Trust 068545/Z/02Wellcome Trust 076113/B/04/ZWellcome Trust 079895Wellcome Trust 085475/B/08/ZWellcome Trust 085475/Z/08/zWellcome Trust 090532/Z/09/ZWellcome Trust 092731Wellcome Trust 095626Wellcome Trust GR069224Wellcome Trust WT084724MAWellcome Trust WT089062Wellcome Trust WT089549
Abstract
objectiveTo quantify genetic overlap between migraine and ischemic stroke (IS) with respect to common genetic variation.
methodsWe applied 4 different approaches to large-scale meta-analyses of genome-wide data on migraine (23,285 cases and 95,425 controls) and IS (12,389 cases and 62,004 controls). First, we queried known genome-wide significant loci for both disorders, looking for potential overlap of signals. We then analyzed the overall shared genetic load using polygenic scores and estimated the genetic correlation between disease subtypes using data derived from these models. We further interrogated genomic regions of shared risk using analysis of covariance patterns between the 2 phenotypes using cross-phenotype spatial mapping.
resultsWe found substantial genetic overlap between migraine and IS using all 4 approaches. Migraine without aura (MO) showed much stronger overlap with IS and its subtypes than migraine with aura (MA). The strongest overlap existed between MO and large artery stroke (LAS; p = 6.4 × 10(-28) for the LAS polygenic score in MO) and between MO and cardioembolic stroke (CE; p = 2.7 × 10(-20) for the CE score in MO).
conclusionsOur findings indicate shared genetic susceptibility to migraine and IS, with a particularly strong overlap between MO and both LAS and CE pointing towards shared mechanisms. Our observations on MA are consistent with a limited role of common genetic variants in this subtype.
Indexed as
Genome-Wide Association StudyBrain IschemiaHumansMigraine with AuraMigraine without AuraStroke
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