SMAD3 negatively regulates serum irisin and skeletal muscle FNDC5 and peroxisome proliferator-activated receptor γ coactivator 1-α (PGC-1α) during exercise.

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

Who cites it

11 citing papers in PubMed.

1. Reexamining Fat: Exploring Diversity, Plasticity, Development, Functional Implication, and Therapeutic Options.International journal of molecular sciences · 2026
   Review
2. Sex-specific increases in myostatin and SMAD3 contribute to obesity-related insulin resistance in human skeletal muscle and primary human myotubes.American journal of physiology. Endocrinology and metabolism · 2024
   Article
3. Revisiting Skeletal Muscle Dysfunction and Exercise in Chronic Obstructive Pulmonary Disease: Emerging Significance of Myokines.Aging and disease · 2023
   Review
4. Irisin Acts via the PGC-1α and BDNF Pathway to Improve Depression-like Behavior.Clinical nutrition research · 2021
   Review
5. Muscle-Bone Crosstalk in Chronic Obstructive Pulmonary Disease.Frontiers in endocrinology · 2021
   Review
6. The Role of Irisin in Alzheimer's Disease.Journal of clinical medicine · 2018
   Review
7. Decreased mitochondrial respiration in aneurysmal aortas of Fibulin-4 mutant mice is linked to PGC1A regulation.Cardiovascular research · 2018
   Article
8. Mitochondrial function in thoracic aortic aneurysms.Cardiovascular research · 2018
   Article
9. Physiology and role of irisin in glucose homeostasis.Nature reviews. Endocrinology · 2017
   Review
10. TGF-β1/Smad3 Pathway Targets PP2A-AMPK-FoxO1 Signaling to Regulate Hepatic Gluconeogenesis.The Journal of biological chemistry · 2017
    Article
11. Irisin regulates cardiac physiology in zebrafish.PloS one · 2017
    Article

Corrections and comments

• Erratum for
  SMAD3 negatively regulates serum irisin and skeletal muscle FNDC5 and peroxisome proliferator-activated receptor γ coactivator 1-α (PGC-1α) during exercise.2015

Authors and funding

3 authors.

Funding

Abstract

PubMed holds no abstract for this paper.