Evidence map›Paper›PMID 25934564›Full record

ReviewClinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association2015

The Art and Science of Diagnosing and Treating Lung and Heart Disease Secondary to Liver Disease.

David S Goldberg, Michael B Fallon

Abstract readReview
In one paragraph

Review in Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 36 citations in OpenAlex.

  1. Review
  2. Beyond the lungs: extending the field-of-view in chest CT with latent diffusion models.Proceedings of SPIE--the International Society for Optical Engineering · 2025
    Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Review
  8. Review
  9. Review
  10. Article
  11. Cirrhotic cardiomyopathy: the liver affects the heart.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2019
    Review
  12. Article
  13. Cardiopulmonary examination.Clinical liver disease · 2016
    Review
  14. Hepatobiliary Quiz (Answers)-16 (2015).Journal of clinical and experimental hepatology · 2015
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

David S GoldbergDivision of Gastroenterology, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania; Center for Clinical Epidemiology and Biostatistics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania; Leonard Davis Institute, University of Pennsylvania, Philadelphia, Pennsylvania. Electronic address: david.goldberg@uphs.upenn.edu.
Michael B FallonDivision of Gastroenterology, Hepatology, and Nutrition, Department of Internal Medicine, The University of Texas Health Science Center at Houston, Houston, Texas.
The University of Texas Health Science Center at Houston · USUniversity of Pennsylvania · US

Funding

Sorafenib for Hepatopulmonary SyndromeUM1HL116886 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI FALLON, MICHAEL B, KAWUT, STEVEN M · 2013 to 2015
$5.1M
Estrogen signaling in portopulmonary hypertensionR01HL113988 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI FALLON, MICHAEL TODD, KAWUT, STEVEN M · 2012 to 2016
$3.8M
A population-based cohort to study outcomes in end-stage liver disease patientsK08DK098272 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI GOLDBERG, DAVID SETH · 2013 to 2017
$786k
NHLBI NIH HHS HL113988NHLBI NIH HHS HL116886NHLBI NIH HHS R01 HL113988NHLBI NIH HHS UM1 HL116886NIDDK NIH HHS K08 DK098272NIDDK NIH HHS K08 DK098272-01A1
6 · The paper itself

Abstract

Patients with chronic liver disease are at risk of extrahepatic complications related to cirrhosis and portal hypertension, as well as organ-specific complications of certain liver diseases. These complications can compromise quality of life, while also increasing morbidity and mortality before and after liver transplantation. Patients with chronic liver disease are at risk for pulmonary complications of hepatopulmonary syndrome and portopulmonary syndrome; the cardiac complication fall under the general concept of cirrhotic cardiomyopathy, which can affect systolic and diastolic function, as well as cardiac conduction. In addition, patients with certain diseases are at risk of lung and/or cardiac complications that are specific to the primary disease (ie, emphysema in α-1-antitrypsin deficiency) or occur with increased incidence in certain conditions (ie, ischemic heart disease associated with nonalcoholic steatohepatitis). This article focuses on the epidemiology, clinical presentation, pathogenesis, treatment options, and role of transplantation for lung and heart diseases secondary to liver disease, while also highlighting select liver diseases that directly affect the lungs and heart.

Indexed as

Liver TransplantationCardiomyopathiesHepatopulmonary SyndromeHumansHypertension, PortalLiver DiseasesHepatopulmonary SyndromePortopulmonary Hypertension

Identifiers

PMID25934564
PMCPMC4618073
OpenAlexW1890809664

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.