Evidence map›Paper›PMID 25934522›Full record

ReviewBest practice & research. Clinical obstetrics & gynaecology2015

Molecular staging of gynecological cancer: What is the future?

Pratibha S Binder, Jaime Prat, David G Mutch

Abstract readReview
In one paragraph

Review in Best practice & research. Clinical obstetrics & gynaecology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Pratibha S BinderDivision of Gynecologic Oncology, Department of Obstetrics and Gynecology, Washington University in St. Louis School of Medicine, St. Louis, MO, USA. Electronic address: binderp@wudosis.wustl.edu.
Jaime PratDepartment of Pathology, Hospital de Sant Pau, Autonomous University of Barcelona, Barcelona, Spain.
David G MutchDivision of Gynecologic Oncology, Department of Obstetrics and Gynecology, Washington University in St. Louis School of Medicine, St. Louis, MO, USA.

Funding

Washington University Institute of Clinical and Translational SciencesUL1TR000448 · NCATS · WASHINGTON UNIVERSITY · PI EVANOFF, BRADLEY A · 2012 to 2016
$41.4M
NCATS NIH HHS UL1 TR000448
6 · The paper itself

Abstract

The purpose of cancer staging is to classify cancers into prognostic groups and to allow for comparison of treatment results and survival between patients and institutions. Staging for gynecologic cancers is based on extent of disease and metastasis, which was historically determined by physical examination and is now based on surgical and histologic examination of tumor specimens. Although the extent of disease is currently considered the most important predictor of recurrence and survival, current staging does not include molecular features that are associated with tumor aggressiveness, response to therapy, and prognosis. This review focuses on genomic and proteomic features of gynecologic cancers and the future of biomarkers in staging classification.

Indexed as

AdenocarcinomaBiomarkers, TumorCarcinoma, EndometrioidCarcinoma, Squamous CellEndometrial NeoplasmsFemaleGenital Neoplasms, FemaleHumansNeoplasm StagingOvarian NeoplasmsPapillomavirus InfectionsPrognosisUterine Cervical NeoplasmsUterine NeoplasmsBiomarkers, Tumorbiomarkergynecologic cancermolecular classificationprognosisstaging

Identifiers

PMID25934522
PMCPMC4532616

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.