Evidence map›Paper›PMID 25934347›Full record

ArticleNuclear medicine and biology2015

Preliminary evaluation of β3-adrenoceptor agonist-induced 18F-FDG metabolic activity of brown adipose tissue in obese Zucker rat.

Kimberly N Schade, Aparna Baranwal, Christopher Liang, M Reza Mirbolooki, Jogeshwar Mukherjee

Abstract readComparative StudyEvaluation Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Nuclear medicine and biology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Frontiers in endocrinology · 2019
    Article
  5. Article
  6. PreclinicalFrontiers in pharmacology · 2016
    Review
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Kimberly N SchadePreclinical Imaging, Department of Radiological Sciences, University of California-Irvine, Irvine, CA 92697.
Aparna BaranwalPreclinical Imaging, Department of Radiological Sciences, University of California-Irvine, Irvine, CA 92697.
Christopher LiangPreclinical Imaging, Department of Radiological Sciences, University of California-Irvine, Irvine, CA 92697.
M Reza MirbolookiPreclinical Imaging, Department of Radiological Sciences, University of California-Irvine, Irvine, CA 92697.
Jogeshwar MukherjeePreclinical Imaging, Department of Radiological Sciences, University of California-Irvine, Irvine, CA 92697. Electronic address: j.mukherjee@uci.edu.
University of California, Irvine · US

Funding

PET Imaging Agent for Diabetes MellitusRC1DK087352 · NIDDK · UNIVERSITY OF CALIFORNIA-IRVINE · PI MUKHERJEE, JOGESHWAR · 2009 to 2010
$985k
Small Animal PET (microPET)S10RR019269 · NCRR · UNIVERSITY OF CALIFORNIA-IRVINE · PI MUKHERJEE, JOGESHWAR · 2007 to 2007
$500k
Small Animal MicroCTS10RR024546 · NCRR · UNIVERSITY OF CALIFORNIA-IRVINE · PI MUKHERJEE, JOGESHWAR · 2009 to 2009
$431k
Imaging Adrenergic Stimulation of Brown Adipose TissueR21DK092917 · NIDDK · UNIVERSITY OF CALIFORNIA-IRVINE · PI MUKHERJEE, JOGESHWAR · 2011 to 2012
$421k
NCRR NIH HHS S10 RR019269NCRR NIH HHS S10 RR024546NIDDK NIH HHS R21 DK092917NIDDK NIH HHS RC1 DK087352
6 · The paper itself

Abstract

backgroundWe have investigated β3-adrenoceptor agonist mediated brown adipose tissue (BAT) activation using (18)F-FDG PET/CT in Zucker lean (ZL) and obese (ZF) rats.

methods(18)F-FDG was injected into ZL and ZF rats pretreated with saline or agonist CL316,243 for scans. (18)F-FDG metabolic activity was computed as standard uptake values.

resultsCL316,243 in ZL activated BAT up to 4-fold compared to saline, while ZF BAT was only up by 2 fold. The decreased activation was consistent with lower β3-adrenoceptor levels in ZF rats.

conclusionsThe genetically modified ZL and ZF rats may provide a useful rat model to evaluate the significance of β3-adrenoceptor agonist-induced BAT activation in obesity.

Indexed as

Adipose Tissue, BrownAdrenergic beta-3 Receptor AgonistsAnimalsDioxolesFluorine RadioisotopesFluorodeoxyglucose F18Isotope LabelingMaleMetabolic Clearance RateObesityPositron-Emission TomographyRadiopharmaceuticalsRatsRats, ZuckerReceptors, Adrenergic, beta-3ThinnessAdrenergic beta-3 Receptor AgonistsDioxolesdisodium (R,R)-5-(2-((2-(3-chlorophenyl)-2-hydroxyethyl)-amino)propyl)-1,3-benzodioxole-2,3-dicarboxylateFluorine RadioisotopesFluorodeoxyglucose F18RadiopharmaceuticalsReceptors, Adrenergic, beta-3(18)F-FDGCL316,243ObesityPET/CTβ3-Adrenoceptor agonist

Identifiers

PMID25934347
PMCPMC4481135
OpenAlexW1965075592

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.