ArticleJournal of the neurological sciences2015
Adult brainstem gliomas: Correlation of clinical and molecular features.
Article in Journal of the neurological sciences, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.
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Who cites it
33 citing papers in PubMed, 1 synthesis or guideline pooled it.
- An integrative survival analysis and a systematic review of the cerebellopontine angle glioblastomas.Scientific reports · 2023Pooled it
- A novel combinatorial therapeutic strategy using resveratrol and viral oncolysis for diffuse intrinsic pontine glioma: an in vitro study.3 Biotech · 2026Article
- Intraoperative Neurophysiological Monitoring During Adult Brainstem Glioma Resection: Association Between Electrophysiological Changes and Early Neurological Outcome.Current oncology (Toronto, Ont.) · 2026Article
- Noninvasive Identification of Isocitrate Dehydrogenase 1/2 Mutation in Brainstem Gliomas.JCO precision oncology · 2026Article
- Analysis of cerebrospinal fluid tumor-derived DNA to obviate biopsy of IDH-mutant brainstem glioma in an adult.The journal of liquid biopsy · 2025Article
- Posterior Fossa Stereotactic Biopsy with Leksell Vantage Frame-Case Series and Review of Literature.Journal of clinical medicine · 2025Review
- Survival and toxicity outcomes of hypofractionated conformal radiotherapy compared to conventionally fractionated radiotherapy in the treatment of diffuse intrinsic pontine gliomas.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2025Article
- Secondary exophytic glioblastoma of the cerebellopontine angle: a case report and review of the literature.Frontiers in oncology · 2025Article
- Brain Stem Glioma Recurrence: Exploring the Therapeutic Frontiers.Journal of personalized medicine · 2024Review
- Case report: A 53-year-old woman with synchronous WHO classification II and IV gliomas.Frontiers in oncology · 2024Article
- Differences in survival prognosticators between children and adults with H3K27M-mutant diffuse midline glioma.CNS neuroscience & therapeutics · 2023Article
- Exploration of the prognostic value of the resection of adult brainstem high-grade glioma based on competing risk model, propensity score matching, and conditional survival rate.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2023Article
- Radiotherapy combined or not with chemotherapy in adult or pediatric patients with brainstem glioma: a population-based study.Reports of practical oncology and radiotherapy : journal of Greatpoland Cancer Center in Poznan and Polish Society of Radiation Oncology · 2023Article
- IDH-mutant Astrocytoma Arising in the Brainstem with Symptom Improvement by Foramen Magnum Decompression: A Case Report.NMC case report journal · 2023Article
- Combined Treatment With Radiotherapy and Immunotherapy for Isocitrate Dehydrogenase Mutant Brainstem Glioma in Adult: A Case Report.Brain tumor research and treatment · 2022Article
- A rare brainstem anaplastic astrocytoma.Translational neuroscience · 2022Article
- Adult brainstem glioma: a multicentre retrospective analysis of 47 Italian patients.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2021Article
- Adult isocitrate dehydrogenase-mutant brainstem glioma: illustrative case.Journal of neurosurgery. Case lessons · 2021Article
- Onco-ontogeny recapitulates phylogeny - a consideration.Oncogene · 2021Article
- Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
backgroundBrainstem gliomas are rare in adults and overall have superior survival outcomes compared to pediatric brainstem gliomas. PATIENTS AND
methodsWe conducted a retrospective data and tissue analysis of all adult patients (≥ 18 years old) with World Health Organization (WHO) Grade II, III, and IV brainstem gliomas in the University of Texas MD Anderson Cancer Center institutional database from 1990 to 2012.
resultsWe identified 143 cases in adults ages 18 and over. There were 28 glioblastomas, 43 anaplastic astrocytomas, 15 diffuse astrocytomas, and 11 gliomas not otherwise specified, and in 46 cases the diagnosis was made radiographically. 128 (89.5%) cases were classified radiographically as diffuse and of the focal tumors, 9 of the 15 were WHO Grade III or IV tumors. Increasing tumor grade and contrast enhancement were associated with significantly reduced overall survival. The median overall survival for the entire cohort was 32.1 months similar to previously published studies. Two of 25 grade II and III tumors, and 1 of 17 glioblastomas had IDH1 mutations on immunohistochemical testing. Nine cases had sufficient tissue for mutation profiling, 1 case had a BRAF V600E mutation and 2 had 2 PIK3CA mutations.
conclusionsSurvival outcomes for adult WHO Grade II to IV brainstem gliomas were similar to supratentorial IDH1 wild-type tumors of similar grade and histology. Potentially actionable mutations can be identified from small biopsy samples in a subset of adult brainstem gliomas.
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