ArticleBiomaterials2015
Deoxycholate bile acid directed synthesis of branched Au nanostructures for near infrared photothermal ablation.
Article in Biomaterials, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 50 citations in OpenAlex.
- Prospect of Gold Nanoparticles in Pancreatic Cancer.Pharmaceutics · 2024Review
- Reactive Oxygen Species Responsive Cleavable Hierarchical Metallic Supra-Nanostructure.Small (Weinheim an der Bergstrasse, Germany) · 2022Article
- Enhanced systemic antilymphoma immune response by photothermal therapy with CpG deoxynucleotide-coated nanoparticles.Blood advances · 2022Article
- Recent progress in cryoablation cancer therapy and nanoparticles mediated cryoablation.Theranostics · 2022Review
- Antibody-conjugated silica-coated gold nanoparticles in targeted therapy of cervical cancer.American journal of translational research · 2022Article
- Recent Advances to Augment NK Cell Cancer Immunotherapy Using Nanoparticles.Pharmaceutics · 2021Review
- Facilitated Buccal Insulin Delivery via Hydrophobic Ion-Pairing Approach: In vitro and ex vivo Evaluation.International journal of nanomedicine · 2021Article
- Responsive Assembly of Silver Nanoclusters with a Biofilm Locally Amplified Bactericidal Effect to Enhance Treatments against Multi-Drug-Resistant Bacterial Infections.ACS central science · 2019Article
- Near-Infrared Fluorescent Endoscopic Image-Guided Photothermal Ablation Therapy of Colorectal Cancer Using Dual-Modal Gold Nanorods Targeting Tumor-Infiltrating Innate Immune Cells in a Transgenic TS4 CRE/APCACS applied materials & interfaces · 2019Article
- Nanofunctionalized Stent-Mediated Local Heat Treatment for the Suppression of Stent-Induced Tissue Hyperplasia.ACS applied materials & interfaces · 2018Article
- Photoperiodic Flower Mimicking Metallic Nanoparticles for Image-Guided Medicine Applications.ACS applied materials & interfaces · 2018Article
- Photoinduced Rapid Transformation from Au Nanoagglomerates to Drug-Conjugated Au Nanovesicles.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2018Article
- Image-Guided Cancer Nanomedicine.Journal of imaging · 2018Article
- Advanced smart-photosensitizers for more effective cancer treatment.Biomaterials science · 2017Article
- Biofunctionalized Hybrid Magnetic Gold Nanoparticles as Catalysts for Photothermal Ablation of Colorectal Liver Metastases.Radiology · 2017Article
- Non-invasive monitoring of branched Au nanoparticle-mediated photothermal ablation.Journal of biomedical materials research. Part B, Applied biomaterials · 2017Article
- Branched Gold Nanoparticle Coating of Clostridium novyi-NT Spores for CT-Guided Intratumoral Injection.Small (Weinheim an der Bergstrasse, Germany) · 2017Article
- Silica-Coated Metal Chelating-Melanin Nanoparticles as a Dual-Modal Contrast Enhancement Imaging and Therapeutic Agent.ACS applied materials & interfaces · 2017Article
- Targeted multimodal nano-reporters for pre-procedural MRI and intra-operative image-guidance.Biomaterials · 2016Article
- Stimuli-Responsive Gold Nanoparticles for Cancer Diagnosis and Therapy.Journal of functional biomaterials · 2016Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
We report an approach for simple, reproducible and high-yield synthesis of branched GNPs directed by deoxycholate bile acid supramolecular aggregates in Au solution. A growth process involving stepwise trapping of the GNP seeds and Au ions in the deoxycholate bile acid solution yields multiple-branched GNPs. Upon NIR laser irradiation strong NIR absorption for branched GNPs induced photothermal-heating to destroy tumor cells. Subsequently, these branched GNPs were biofunctionalized with cRGD cell penetrating-targeting peptides for photothermal cancer treatment applications. Branched GNPs conjugated with cRGD peptides enhanced internalization of the branched GNPs in BxPC3 human pancreatic adenocarcinoma cells and effectively ablated BxPC3 cells when irradiated with a NIR laser (808 nm). Their potential use as photothermal transducing agents was demonstrated in in vivo settings using a pancreatic cancer xenograft model. The tumors were effectively ablated with cRGD-branched GNPs injection and laser exposure without any observation of tumor recurrence. This firstly reported method for deoxycholate bile acid directed synthesis of branched GNPs opens new possibilities for the production of strong NIR absorbing nanostructures for selective nano-photothermolysis of cancer cells and the further design of novel materials with customized spectral and structural properties for broader applications.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.