ArticleThe Journal of chemical physics2015
Communication: Microsecond dynamics of the protein and water affect electron transfer in a bacterial bc(1) complex.
Article in The Journal of chemical physics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 20 citations in OpenAlex.
- Long-Range Conductivity in Proteins Mediated by Aromatic Residues.ACS physical chemistry Au · 2023Article
- Electrochemical response of surface-attached redox DNA governed by low activation energy electron transfer kinetics.Chemical science · 2023Article
- Electron-transfer chain in respiratory complex I.Scientific reports · 2017Article
- Polarizability of the active site of cytochrome c reduces the activation barrier for electron transfer.Scientific reports · 2016Article
- Photosynthetic diode: electron transport rectification by wetting the quinone cofactor.Physical chemistry chemical physics : PCCP · 2015Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Cross-membrane electron transport between cofactors localized in proteins of mitochondrial respiration and bacterial photosynthesis is the source of all biological energy. The statistics and dynamics of nuclear fluctuations in these protein/membrane/water heterogeneous systems are critical for their energetic efficiency. The results of 13 μs of atomistic molecular dynamics simulations of the membrane-bound bc1 bacterial complex are analyzed here. The reaction is affected by a broad spectrum of nuclear modes, with the slowest dynamics in the range of time-scales ∼0.1-1.6 μs contributing half of the reaction reorganization energy. Two reorganization energies are required to describe protein electron transfer due to dynamical arrest of protein conformations on the observation window. This mechanistic distinction allows significant lowering of activation barriers for reactions in proteins.
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