Evidence map›Paper›PMID 25933743›Full record

ArticleEuropean radiology2016

Assessment of the residual tumour of colorectal liver metastases after chemotherapy: diffusion-weighted MR magnetic resonance imaging in the peripheral and entire tumour.

Mathilde Wagner, Maxime Ronot, Sabrina Doblas, Céline Giraudeau, Bernard Van Beers, Jacques Belghiti, Valérie Paradis, Valérie Vilgrain

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Article in European radiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
3.0field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 24 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 1 country.

Mathilde WagnerINSERM, UMR 1149, Paris Diderot University, 100, Bd du Général Leclerc, 92110, Clichy, France. wagner.mathilde@gmail.com.
Maxime RonotINSERM, UMR 1149, Paris Diderot University, 100, Bd du Général Leclerc, 92110, Clichy, France.
Sabrina DoblasINSERM, UMR 1149, Paris Diderot University, 100, Bd du Général Leclerc, 92110, Clichy, France.
Céline GiraudeauINSERM, UMR 1149, Paris Diderot University, 100, Bd du Général Leclerc, 92110, Clichy, France.
Bernard Van BeersINSERM, UMR 1149, Paris Diderot University, 100, Bd du Général Leclerc, 92110, Clichy, France.
Jacques BelghitiHepatobiliary Surgery Department, Beaujon Hospital, University Hospitals Paris Nord Val de Seine, Assistance Publique-Hôpitaux de Paris, APHP, Clichy, France.
Valérie ParadisPathology Department, Beaujon Hospital, University Hospitals Paris Nord Val de Seine, Assistance Publique-Hôpitaux de Paris, APHP, Clichy, France.
Valérie VilgrainINSERM, UMR 1149, Paris Diderot University, 100, Bd du Général Leclerc, 92110, Clichy, France.
Délégation Paris 7 · FRHôpital Beaujon · FRAssistance Publique – Hôpitaux de Paris · FRInserm · FRUniversité Paris Cité · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo evaluate the value of diffusion-weighted imaging (DWI) in detecting residual tumours (RTs) in colorectal liver metastases (CLMs) following chemotherapy, with a focus on tumour periphery.

methodsFrom January 2009-January 2012, 57 patients who underwent liver resection for CLMs with preoperative MRI (<3 months) including DWI were retrospectively included. CLMs were classified into three response groups on pathology: (1) major histological (MHR, RTs ≤ 10 %), (2) partial histological (PHR, RT = 10-49 %), and (3) no histological (NHR, RT ≥ 50 %). On DWI, regions of interest (ROIs) were drawn around the entire tumour and tumour periphery. Apparent diffusion (ADC) and pure diffusion (D) coefficients were calculated using a monoexponential fit, and compared using Kruskal-Wallis test on a lesion-per-lesion analysis.

results111 CLMs were included. Fourteen (12.5 %), 42 (38 %) and 55 (49.5 %) CLMs presented a MHR, PHR and NHR, respectively. ADC and D of the peripheral ROIs were significantly higher in the MHR group (P = 0.013/P = 0.013). ADC and D from the entire tumour were not significantly different among the groups (P = 0.220/P = 0.103).

conclusionIn CLM treated with chemotherapy, ADC and D values from the entire tumour are not related to the degree of RT, while peripheral zone diffusion parameters could help identify metastases with MHR. KEY POINTS: Peripheral ADC and D of CLMs were higher with major pathological responses. Global ADC and D of CLMs were not different according to residual tumour. Diffusion-weighted images of CLM periphery could be an interesting biomarker of MHR. Diffusion-weighted images could be used to help tailor treatment.

Indexed as

AdultAgedAged, 80 and overAntineoplastic AgentsColorectal NeoplasmsDiffusion Magnetic Resonance ImagingFemaleHumansLiver NeoplasmsMaleMiddle AgedNeoplasm, ResidualRetrospective StudiesAntineoplastic AgentsColorectal cancerDiffusion weighted-imagingLesion peripheryLiver metastasesResidual tumours

Identifiers

PMID25933743
OpenAlexW2066895093

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.