ArticlePLoS genetics2015
Regulation of Active DNA Demethylation by a Methyl-CpG-Binding Domain Protein in Arabidopsis thaliana.
Article in PLoS genetics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 57 citations in OpenAlex.
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- RH3 enhances antiviral defense by facilitating small RNA loading into Argonaute 2 at endoplasmic reticulum-chloroplast membrane contact sites.Nature communications · 2025Article
- Roles of methyl-CpG-binding-domain (MBD) protiens in regulation of biological processes in plants.Physiology and molecular biology of plants : an international journal of functional plant biology · 2025Review
- Characterization of DNA methylation reader proteins inGenome research · 2024Article
- The MBD-ACD DNA methylation reader complex recruits MICRORCHIDIA6 to regulate ribosomal RNA gene expression in Arabidopsis.The Plant cell · 2024Article
- DNA methylation and lipid metabolism are involved in GA-induced maize aleurone layers PCD as revealed by transcriptome analysis.BMC plant biology · 2023Article
- Base Excision DNA Repair in Plants:International journal of molecular sciences · 2023Review
- MBD3 Regulates Male Germ Cell Division and Sperm Fertility inPlants (Basel, Switzerland) · 2023Article
- ALBA proteins confer thermotolerance through stabilizing HSF messenger RNAs in cytoplasmic granules.Nature plants · 2022Article
- Genome-Wide Characterization of the Methyl CpG Binding Domain-Containing Proteins in Watermelon and Functional Analysis of Their Roles in Disease Resistance Through Ectopic Overexpression inFrontiers in plant science · 2022Article
- Biological role and mechanism of chromatin readers in plants.Current opinion in plant biology · 2021Review
- DEAD-box helicases modulate dicing body formation inScience advances · 2021Article
- Overexpression of a methyl-CpG-binding protein gene OsMBD707 leads to larger tiller angles and reduced photoperiod sensitivity in rice.BMC plant biology · 2021Article
- Involvement of MEM1 in DNA demethylation in Arabidopsis.Plant molecular biology · 2020Article
- Histone acetylation recruits the SWR1 complex to regulate active DNA demethylation inProceedings of the National Academy of Sciences of the United States of America · 2019Article
- An overview of designing and selection of sgRNAs for precise genome editing by the CRISPR-Cas9 system in plants.3 Biotech · 2019Article
- AtMBD4: A methylated DNA binding protein negatively regulates a subset of phosphate starvation genes.Journal of biosciences · 2019Article
Corrections and comments
- Erratum issued
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Active DNA demethylation plays crucial roles in the regulation of gene expression in both plants and animals. In Arabidopsis thaliana, active DNA demethylation is initiated by the ROS1 subfamily of 5-methylcytosine-specific DNA glycosylases via a base excision repair mechanism. Recently, IDM1 and IDM2 were shown to be required for the recruitment of ROS1 to some of its target loci. However, the mechanism(s) by which IDM1 is targeted to specific genomic loci remains to be determined. Affinity purification of IDM1- and IDM2- associating proteins demonstrated that IDM1 and IDM2 copurify together with two novel components, methyl-CpG-binding domain protein 7 (MBD7) and IDM2-like protein 1 (IDL1). IDL1 encodes an α-crystallin domain protein that shows high sequence similarity with IDM2. MBD7 interacts with IDM2 and IDL1 in vitro and in vivo and they form a protein complex associating with IDM1 in vivo. MBD7 directly binds to the target loci and is required for the H3K18 and H3K23 acetylation in planta. MBD7 dysfunction causes DNA hypermethylation and silencing of reporter genes and a subset of endogenous genes. Our results suggest that a histone acetyltransferase complex functions in active DNA demethylation and in suppression of gene silencing at some loci in Arabidopsis.
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