ArticlePloS one2015
Health providers' perceptions of clinical trials: lessons from Ghana, Kenya and Burkina Faso.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 22 citations in OpenAlex.
- Through the eyes of the participant: using photovoice to understand the experiences and effects of ivermectin MDA in the context of the BOHEMIA clinical trial in Kwale, Kenya.Malaria journal · 2025Article
- Unveiling the global impact of hypertensive heart disease among individuals aged ≥ 65 years: metabolic risk factors and future projections for 2050.Frontiers in nutrition · 2025Article
- Healthcare Provider Perspectives on HIV Cure Research in Ghana.AIDS research and treatment · 2023Article
- Barriers for cancer clinical trial enrollment: A qualitative study of the perspectives of healthcare providers.Contemporary clinical trials communications · 2022Article
- COVID-19 vaccine research and development: ethical issues.Tropical medicine & international health : TM & IH · 2021Review
- Disseminating clinical study results to trial participants in Ethiopia: insights and lessons learned.Malaria journal · 2020Article
- Health workers' perceptions and challenges in implementing meningococcal serogroup a conjugate vaccine in the routine childhood immunization schedule in Burkina Faso.BMC public health · 2020Article
- The state of enrollment on the National Health Insurance Scheme in rural Ghana after eight years of implementation.International journal for equity in health · 2019Article
- Logistics of Implementing a Large-scale Typhoid Vaccine Trial in Kathmandu, Nepal.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2019Article
- Community perception regarding childhood vaccinations and its implications for effectiveness: a qualitative study in rural Burkina Faso.BMC public health · 2018Article
- Good collaborative practice: reforming capacity building governance of international health research partnerships.Globalization and health · 2018Article
- "We were being treated like the Queen": understanding trial factors influencing high paediatric malaria treatment adherence in western Kenya.Malaria journal · 2018Article
- Dengue rapid diagnostic tests: Health professionals' practices and challenges in Burkina Faso.SAGE open medicine · 2018Article
- "You can save time if…"-A qualitative study on internal factors slowing down clinical trials in Sub-Saharan Africa.PloS one · 2017Article
- The role of corruption and unethical behaviour in precluding the placement of industry sponsored clinical trials in sub-Saharan Africa: Stakeholder views.Contemporary clinical trials communications · 2016Article
- Clinical Trials Cannot Substitute for Health System Strengthening Initiatives or Specifically Designed Health Policy and Systems Research.The American journal of bioethics : AJOB · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors at 5 institutions in 5 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundClinical trials conducted in Africa often require substantial investments to support trial centres and public health facilities. Trial resources could potentially generate benefits for routine health service delivery but may have unintended consequences. Strengthening ethical practice requires understanding the potential effects of trial inputs on the perceptions and practices of routine health care providers. This study explores the influence of malaria vaccine trials on health service delivery in Ghana, Kenya and Burkina Faso.
methodsWe conducted: audits of trial inputs in 10 trial facilities and among 144 health workers; individual interviews with frontline providers (n=99) and health managers (n=14); and group discussions with fieldworkers (n=9 discussions). Descriptive summaries were generated from audit data. Qualitative data were analysed using a framework approach.
resultsFacilities involved in trials benefited from infrastructure and equipment upgrades, support with essential drugs, access to trial vehicles, and placement of additional qualified trial staff. Qualified trial staff in facilities were often seen as role models by their colleagues; assisting with supportive supervision and reducing facility workload. Some facility staff in place before the trial also received formal training and salary top-ups from the trials. However, differential access to support caused dissatisfaction, and some interviewees expressed concerns about what would happen at the end of the trial once financial and supervisory support was removed.
conclusionClinical trials function as short-term complex health service delivery interventions in the facilities in which they are based. They have the potential to both benefit facilities, staff and communities through providing the supportive environment required for improvements in routine care, but they can also generate dissatisfaction, relationship challenges and demoralisation among staff. Minimising trial related harm and maximising benefits requires careful planning and engagement of key actors at the outset of trials, throughout the trial and on its' completion.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.