ArticleJournal of developmental and behavioral pediatrics : JDBP
Serotonin Transporter Genotype (5HTTLPR) Moderates the Longitudinal Impact of Atypical Attachment on Externalizing Behavior.
Article in Journal of developmental and behavioral pediatrics : JDBP. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.
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Who cites it
5 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Comparing Long-Term Placement Outcomes of Residential and Family Foster Care: A Meta-Analysis.Trauma, violence & abuse · 2019Pooled it
- Foster care promotes adaptive functioning in early adolescence among children who experienced severe, early deprivation.Journal of child psychology and psychiatry, and allied disciplines · 2018Trial
- Serotonergic sensitivity alleles moderate relations between attachment security at age three and socioemotional competence at age five.Developmental psychobiology · 2021Article
- Early Rearing Conditions Affect Monoamine Metabolite Levels During Baseline and Periods of Social Separation Stress: A Non-human Primate Model (Frontiers in human neuroscience · 2021Article
- Gene and environment interaction: Is the differential susceptibility hypothesis relevant for obesity?Neuroscience and biobehavioral reviews · 2017Review
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Authors and funding
5 authors.
Funding
Abstract
objectiveTo test whether genotype of the serotonin transporter-linked polymorphic region (5HTTLPR) and atypical attachment interact to predict externalizing psychopathology prospectively in a sample of children with a history of early institutional care.
methodsCaregiver report of externalizing behavior at 54 months was examined in 105 children initially reared in institutional care and enrolled in the Bucharest Early Intervention Project, a randomized controlled trial of high quality foster care. 5HTTLPR genotype, attachment status at 42 months of age (typical [secure, avoidant, or ambivalent] or atypical [disorganized-controlling, insecure-other]), and their interaction were examined as predictors of externalizing behavior at age 54 months.
results5HTTLPR genotype and atypical attachment at age 42 months interacted to predict externalizing behavior at age 54 months. Specifically, children with the s/s genotype with an atypical attachment had the highest externalizing scores. However, s/s children with a typical attachment demonstrated the lowest externalizing scores, even after controlling for intervention group status. There was no association between attachment status and externalizing behavior among children carrying at least 1 copy of the l allele.
conclusionThese findings indicate that genetic variation in the serotonergic system moderates the association between atypical attachment status and externalizing in young children. Our findings suggest that children, as a result of genetic variability in the serotonergic system, demonstrate differential sensitivity to the attachment relationship.
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