ArticleEndocrinology2015
Adrenal Development in Mice Requires GATA4 and GATA6 Transcription Factors.
Article in Endocrinology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 32 citations in OpenAlex.
- The transcription factor HHEX maintains glucocorticoid levels and protects adrenals from androgen-induced lipid depletion.Nature communications · 2026Article
- The Steroidogenic Acute Regulatory (STAR) Gene Anatomy, Expression, and Roles.Development & reproduction · 2025Review
- Current insight into the transient X-zone in the adrenal gland cortex.Vitamins and hormones · 2024Review
- Generation of glucocorticoid-producing cells derived from human pluripotent stem cells.Cell reports methods · 2023Article
- Development and function of the fetal adrenal.Reviews in endocrine & metabolic disorders · 2023Review
- Development of Human Adrenocortical Adenoma (HAA1) Cell Line from Zona Reticularis.International journal of molecular sciences · 2022Article
- Transgenic Mouse Models to Study the Development and Maintenance of the Adrenal Cortex.International journal of molecular sciences · 2022Review
- GATA6 is a crucial factor for Myocd expression in the visceral smooth muscle cell differentiation program of the murine ureter.Development (Cambridge, England) · 2022Article
- The developmental origin and the specification of the adrenal cortex in humans and cynomolgus monkeys.Science advances · 2022Article
- Targeted Disruption of Lats1 and Lats2 in Mice Impairs Adrenal Cortex Development and Alters Adrenocortical Cell Fate.Endocrinology · 2020Article
- DLK1/PREF1 marks a novel cell population in the human adrenal cortex.The Journal of steroid biochemistry and molecular biology · 2019Article
- At the Crossroads of Fate-Somatic Cell Lineage Specification in the Fetal Gonad.Endocrine reviews · 2018Review
- Probing GATA factor function in mouse Leydig cells via testicular injection of adenoviral vectors.Reproduction (Cambridge, England) · 2017Article
- The prevalence of CTNNB1 mutations in primary aldosteronism and consequences for clinical outcomes.Scientific reports · 2017Article
- Functional Zonation of the Adult Mammalian Adrenal Cortex.Frontiers in neuroscience · 2016Review
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
The adrenal glands consist of an outer cortex and an inner medulla, and their primary purposes include hormone synthesis and secretion. The adrenal cortex produces a complex array of steroid hormones, whereas the medulla is part of the sympathetic nervous system and produces the catecholamines epinephrine and norepinephrine. In the mouse, GATA binding protein (GATA) 4 and GATA6 transcription factors are coexpressed in several embryonic tissues, including the adrenal cortex. To explore the roles of GATA4 and GATA6 in mouse adrenal development, we conditionally deleted these genes in adrenocortical cells using the Sf1Cre strain of animals. We report here that mice with Sf1Cre-mediated double deletion of Gata4 and Gata6 genes lack identifiable adrenal glands, steroidogenic factor 1-positive cortical cells and steroidogenic gene expression in the adrenal location. The inactivation of the Gata6 gene alone (Sf1Cre;Gata6(flox/flox)) drastically reduced the adrenal size and corticosterone production in the adult animals. Adrenocortical aplasia is expected to result in the demise of the animal within 2 weeks after birth unless glucocorticoids are provided. In accordance, Sf1Cre;Gata4(flox/flox)Gata6(flox/flox) females depend on steroid supplementation to survive after weaning. Surprisingly, Sf1Cre;Gata4(flox/flox)Gata6(flox/flox) males appear to live normal lifespans as vital steroidogenic synthesis shifts to their testes. Our results reveal a requirement for GATA factors in adrenal development and provide a novel tool to characterize the transcriptional network controlling adrenocortical cell fates.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.