ArticlePloS one2015
Long term non-invasive ventilation in children: impact on survival and transition to adult care.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
37 citing papers in PubMed, 2 syntheses or guidelines pooled it, 123 citations in OpenAlex.
- Paediatric Long-Term Home Respiratory Support: Recommendations of the Swiss Society of Paediatric Pulmonology.Respiration; international review of thoracic diseases · 2026Guideline
- Liberation and mortality outcomes in pediatric long-term ventilation: A qualitative systematic review.Pediatric pulmonology · 2020Pooled it
- Pilot evaluation of 3D-designed custom-made integrated mask and headgear for children using non-invasive ventilation.BMJ open respiratory research · 2026Article
- Understanding the perceptions and experiences of adults with early-onset neuromuscular disorders using noninvasive ventilation in making healthcare decisions.ERJ open research · 2026Article
- Indications for home mechanical ventilation in children: changes over four decades.European journal of pediatrics · 2025Article
- No socioeconomic disparities in the availability of personal care assistance: a population-based cohort analysis of children living with respiratory support.International journal for equity in health · 2025Article
- Swedish national cohort of children living with long-term respiratory support (DISCOVERY-P): cohort profile.BMJ open · 2025Article
- The transition from children to young people living with home mechanical ventilation.International journal of qualitative studies on health and well-being · 2024Article
- Article
- The role of telemonitoring in patients on home mechanical ventilation.European respiratory review : an official journal of the European Respiratory Society · 2023Review
- Home mechanical ventilation in children with chronic respiratory failure: a narrative review.Journal of Yeungnam medical science · 2023Article
- Health System Factors Affecting the Experience of Non-Invasive Ventilation Provision of People with Neuromuscular Disorders in New Zealand.International journal of environmental research and public health · 2023Article
- Highlights from the Respiratory Failure and Mechanical Ventilation 2022 Conference.ERJ open research · 2023Article
- Long-term health-related quality of life in patients on home mechanical ventilation.BMC pulmonary medicine · 2022Article
- Pediatric Average Volume Assured Pressure Support.Frontiers in pediatrics · 2022Review
- Ventilatory support at home for children: A joint position paper from the Thoracic Society of Australia and New Zealand/Australasian Sleep Association.Respirology (Carlton, Vic.) · 2021Review
- Average volume-assured pressure support vs conventional bilevel pressure support in pediatric nocturnal hypoventilation: a case series.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2021Article
- Home mechanical ventilation: back to basics.Acute and critical care · 2020Article
- Characteristics and outcomes in children on long-term mechanical ventilation: the experience of a pediatric tertiary center in Rome.Italian journal of pediatrics · 2020Article
- Follow-Up and Monitoring of Children Needing Long Term Home Ventilation.Frontiers in pediatrics · 2020Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe number of children receiving domiciliary ventilatory support has grown over the last few decades driven largely by the introduction and widening applications of non-invasive ventilation. Ventilatory support may be used with the intention of increasing survival, or to facilitate discharge home and/or to palliate symptoms. However, the outcome of this intervention and the number of children transitioning to adult care as a consequence of longer survival is not yet clear.
methodsIn this retrospective cohort study, we analysed the outcome in children (<17 years) started on home NIV at Royal Brompton Hospital over an 18 year period 1993-2011. The aim was to establish for different diagnostic groups: survival rate, likelihood of early death depending on diagnosis or discontinuation of ventilation, and the proportion transitioning to adult care.
results496 children were commenced on home non invasive ventilation; follow-up data were available in 449 (91%). Fifty six per cent (n=254) had neuromuscular disease. Ventilation was started at a median age (IQR) 10 (3-15) years. Thirteen percent (n=59) were less than 1 year old. Forty percent (n=181) have transitioned to adult care. Twenty four percent (n=109) of patients have died, and nine percent (n=42) were able to discontinue ventilatory support.
conclusionLong term ventilation is associated with an increase in survival in a range of conditions leading to ventilatory failure in children, resulting in increasing numbers surviving to adulthood. This has significant implications for planning transition and adult care facilities.
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