ArticleEpigenetics2015
Combined epigenetic and intraspecific variation of the DRD4 and SERT genes influence novelty seeking behavior in great tit Parus major.
Article in Epigenetics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 69 citations in OpenAlex.
- Urbanisation Drives Microevolution in the Egyptian Fruit Bat (Evolutionary applications · 2026Article
- Low genetic differentiation and symmetric migration between urban and forest populations of great tits.Biologia futura · 2025Article
- Molecular characterization of chicken DA systems reveals that the avian personality gene,Frontiers in neuroanatomy · 2025Article
- Early developmental carry-over effects on exploratory behaviour and DNA methylation in wild great tits (Evolutionary applications · 2024Article
- The genomic response to urbanization in the damselflyEvolutionary applications · 2023Article
- Variation in DNA Methylation in Avian Nestlings Is Largely Determined by Genetic Effects.Molecular biology and evolution · 2023Article
- Molecular biology of serotonergic systems in avian brains.Frontiers in molecular neuroscience · 2023Review
- Are behaviour and stress-related phenotypes in urban birds adaptive?The Journal of animal ecology · 2022Article
- The effect of experimental lead pollution on DNA methylation in a wild bird population.Epigenetics · 2022Article
- Article
- Epigenetics and the city: Non-parallel DNA methylation modifications across pairs of urban-forest Great tit populations.Evolutionary applications · 2022Article
- Serotonin transporter (SERT) polymorphisms, personality and problem-solving in urban great tits.Scientific reports · 2021Article
- Does Arsenic Contamination Affect DNA Methylation Patterns in a Wild Bird Population? An Experimental Approach.Environmental science & technology · 2021Article
- Genetic association with boldness and maternal performance in a free-ranging population of grey seals (Halichoerus grypus).Heredity · 2021Article
- The serotonin transporter gene and female personality variation in a free-living passerine.Scientific reports · 2021Article
- Urbanization is associated with modifications in DNA methylation in a small passerine bird.Evolutionary applications · 2021Article
- On the Use of Blood Samples for Measuring DNA Methylation in Ecological Epigenetic Studies.Integrative and comparative biology · 2020Review
- Biologia Futura: adaptive changes in urban populations.Biologia futura · 2020Article
- DNA methylation in canine brains is related to domestication and dog-breed formation.PloS one · 2020Article
- Developmental conditions modulate DNA methylation at the glucocorticoid receptor gene with cascading effects on expression and corticosterone levels in zebra finches.Scientific reports · 2019Article
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Authors and funding
5 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
DNA methylation is one of the main epigenetic mechanisms that can regulate gene expression and is an important means for creating phenotypic variation. In the present study, we performed methylation profiling of 2 candidate genes for personality traits, namely DRD4 and SERT, in the great tit Parus major to ascertain whether personality traits and behavior within different habitats have evolved with the aid of epigenetic variation. We applied bisulphite PCR and strand-specific sequencing to determine the methylation profile of the CpG dinucleotides in the DRD4 and SERT promoters and also in the CpG island overlapping DRD4 exon 3. Furthermore, we performed pyrosequencing to quantify the total methylation levels at each CpG location. Our results indicated that methylation was ∼1-4% higher in urban than in forest birds, for all loci and tissues analyzed, suggesting that this epigenetic modification is influenced by environmental conditions. Screening of genomic DNA sequence revealed that the SERT promoter is CpG poor region. The methylation at a single CpG dinucleotide located 288 bp from the transcription start site was related to exploration score in urban birds. In addition, the genotypes of the SERT polymorphism SNP234 located within the minimal promoter were significantly correlated with novelty seeking behavior in captivity, with the allele increasing this behavior being more frequent in urban birds. As a conclusion, it seems that both genetic and methylation variability of the SERT gene have an important role in shaping personality traits in great tits, whereas genetic and methylation variation at the DRD4 gene is not strongly involved in behavior and personality traits.
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