ArticlePloS one2015
Actin as deathly switch? How auxin can suppress cell-death related defence.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 42 citations in OpenAlex.
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- Dedifferentiation of Plant Cells: A Term Covering Multiple Pathways?Plants (Basel, Switzerland) · 2026Article
- Unleash the dogs of death: metacaspase 5, microtubules, and hypersensitive response.Plant cell reports · 2025Article
- Omic characterisation of multi-component defences against the necrotrophic pathogen Pyrenophora tritici-repentis in wheat.Plant biology (Stuttgart, Germany) · 2025Article
- Kinetin induces microtubular breakdown, cell cycle arrest and programmed cell death in tobacco BY-2 cells.Protoplasma · 2023Article
- Cell type matters: competence for alkaloid metabolism differs in two seed-derived cell strains of Catharanthus roseus.Protoplasma · 2023Article
- Switching cell fate by the actin-auxin oscillator in Taxus: cellular aspects of plant cell fermentation.Plant cell reports · 2022Article
- Cold-Induced Nuclear Import of CBF4 Regulates Freezing Tolerance.International journal of molecular sciences · 2022Article
- Phosphatidic Acid in Plant Hormonal Signaling: From Target Proteins to Membrane Conformations.International journal of molecular sciences · 2022Review
- The fungal elicitor eutypine fromHorticulture research · 2022Article
- Dissecting the membrane-microtubule sensor in grapevine defence.Horticulture research · 2021Article
- Hunting modulators of plant defence: the grapevine trunk disease fungus Eutypa lata secretes an amplifier for plant basal immunity.Journal of experimental botany · 2020Article
- Auxin protects Arabidopsis thaliana cell suspension cultures from programmed cell death induced by the cellulose biosynthesis inhibitors thaxtomin A and isoxaben.BMC plant biology · 2019Article
- A specific allele of MYB14 in grapevine correlates with high stilbene inducibility triggered by AlPlant cell reports · 2019Article
- Grapevine fatty acid hydroperoxide lyase generates actin-disrupting volatiles and promotes defence-related cell death.Journal of experimental botany · 2018Article
- Two dominant loci determine resistance to Phomopsis cane lesions in FTAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2018Article
- A rice class-XIV kinesin enters the nucleus in response to cold.Scientific reports · 2018Article
- Class XI Myosins Contribute to Auxin Response and Senescence-Induced Cell Death inFrontiers in plant science · 2018Article
- Article
- The Pseudomonas syringae Type III Effector HopG1 Induces Actin Remodeling to Promote Symptom Development and Susceptibility during Infection.Plant physiology · 2016Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Plant innate immunity is composed of two layers--a basal immunity, and a specific effector-triggered immunity, which is often accompanied by hypersensitive cell death. Initiation of cell death depends on a complex network of signalling pathways. The phytohormone auxin as central regulator of plant growth and development represents an important component for the modulation of plant defence. In our previous work, we showed that cell death is heralded by detachment of actin from the membrane. Both, actin response and cell death, are triggered by the bacterial elicitor harpin in grapevine cells. In this study we investigated, whether harpin-triggered actin bundling is necessary for harpin-triggered cell death. Since actin organisation is dependent upon auxin, we used different auxins to suppress actin bundling. Extracellular alkalinisation and transcription of defence genes as the basal immunity were examined as well as cell death. Furthermore, organisation of actin was observed in response to pharmacological manipulation of reactive oxygen species and phospholipase D. We find that induction of defence genes is independent of auxin. However, auxin can suppress harpin-induced cell death and also counteract actin bundling. We integrate our findings into a model, where harpin interferes with an auxin dependent pathway that sustains dynamic cortical actin through the activity of phospholipase D. The antagonism between growth and defence is explained by mutual competition for signal molecules such as superoxide and phosphatidic acid. Perturbations of the auxin-actin pathway might be used to detect disturbed integrity of the plasma membrane and channel defence signalling towards programmed cell death.
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