Evidence map›Paper›PMID 25932696›Full record

Trial reportNursing research

Factors associated with feeding progression in extremely preterm infants.

Jinhee Park, George Knafl, Suzanne Thoyre, Debra Brandon

Registry-linked trialOpen access · greenAbstract readRandomized Controlled Trial
In one paragraph

Trial report in Nursing research. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03631979 (Regular Intestinal Lavage to Promote Enteral Feeding and Prevent Necrotizing Enterocolitis in Extremely Preterm Infants. A Randomized Controlled Trial Protocol), which is not on this map. Cited by 38 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed, 3 pooled it
6.6field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03631979 naterminatednot on this map

Regular Intestinal Lavage to Promote Enteral Feeding and Prevent Necrotizing Enterocolitis in Extremely Preterm Infants. A Randomized Controlled Trial Protocol

TypeinterventionalSponsorUppsala County Council, SwedenRan2018 to 2025Enrolled200ConditionsNecrotizing Enterocolitis, Time to Full Enteral NutritionArmsIntestinal lavage with normal saline
3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 3 syntheses or guidelines pooled it, 98 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. We're going bananas! The effectiveness and safety of banana puree as an intervention for improving oral feeding in a level IV NICU.Journal of perinatology : official journal of the California Perinatal Association · 2026
    Article
  5. Relationship between feeding milestones and comorbidities with the postnatal growth in preterm infants.Journal of perinatology : official journal of the California Perinatal Association · 2026
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  16. Observational
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  18. Developing the Mansoura Early Feeding Skills Assessment Scale for Preterm Infants.Pediatric gastroenterology, hepatology & nutrition · 2023
    Article
  19. A Unique Clinical Tool for the Evaluation of Oral Feeding Skills in Infants.Canadian journal of occupational therapy. Revue canadienne d'ergotherapie · 2023
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Jinhee ParkJinhee Park, PhD, RN, is Postdoctoral Associate, Duke University School of Nursing, Durham, North Carolina. George Knafl, PhD, is Professor, School of Nursing, University of North Carolina, Chapel Hill. Suzanne Thoyre, PhD, RN, FAAN, is Professor and Director of PhD and Postdoctoral Programs, School of Nursing, University of North Carolina, Chapel Hill. Debra Brandon, PhD, RN, CCNS, FAAN, is Associate Professor and Director of PhD and Postdoctoral Programs, School of Nursing, Duke University, Durham, North Carolina.
George Knafl
Suzanne Thoyre
Debra Brandon
University of North Carolina at Chapel Hill · USApple (Israel) · IL

Funding

Preterm Infants: Light Effects on Health and DevelopmentR01NR008044 · NINR · DUKE UNIVERSITY · PI BRANDON, DEBRA H · 2003 to 2007
$1.6M
NINR NIH HHS R01 NR008044
6 · The paper itself

Abstract

backgroundAmong infants born prematurely, competence at oral feeding is necessary for growth and hospital discharge. Extremely preterm (EP) infants (28 weeks of gestational age [GA]) are at risk for a variety of medical complications, which can limit the infant's capacity to develop oral feeding competence.

objectiveThis study examined feeding progression by assessing timing of acquisition of five early feeding milestones among EP infants and the impact of immaturity and medical complications.

designA chart review was conducted for 94 EP infants who participated in a larger longitudinal randomized study. Feeding progression was defined as infants' postmenstrual age (PMA) at five milestones: first enteral feeding, full enteral feeding, first oral feeding, half oral feeding, and full oral feeding. GA at birth and five medical complications (neurological risk, bronchopulmonary dysplasia, necrotizing enterocolitis, patent ductus arteriosus, and gastroesophageal reflux disease) were used as potential factors influencing the feeding progression. Linear mixed models were used to examine feeding progression across the milestones and contributions of GA at birth and five medical complications on the progression, after controlling for milk type as a covariate.

resultEP infants gradually achieved feeding milestones; however, the attainment of the feeding milestones slowed significantly for infants with younger GA at birth and the presence of medical complications, including neurological risk, bronchopulmonary dysplasia, necrotizing enterocolitis, and patent ductus arteriosus but not gastroesophageal reflux disease. Milk type was a significant covariate for all analyses, suggesting that infants fed with breast milk achieved each of five milestones earlier than formula-fed infants. DISCUSSION: Improved understanding of the timing of essential feeding milestones among EP infants and the contribution of specific medical conditions to the acquisition of these milestones may allow for more targeted care to support feeding skill development.

Indexed as

Bottle FeedingBreast FeedingEnteral NutritionAge FactorsChild DevelopmentEatingFemaleHumansInfant, Extremely PrematureInfant FormulaInfant, NewbornInfant, Premature, DiseasesLongitudinal StudiesMaleMilk, HumanPhototherapy

Identifiers

PMID25932696
PMCPMC4418036
OpenAlexW2334310688

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.