ArticlePloS one2015
MARK/Par1 Kinase Is Activated Downstream of NMDA Receptors through a PKA-Dependent Mechanism.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 23 citations in OpenAlex.
- Neuronal connectivity, behavioral, and transcriptional alterations associated with the loss of MARK2.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2024Article
- MARK1 regulates dendritic spine morphogenesis and cognitive functions in vivo.Experimental neurology · 2024Article
- Liver kinase B-1 modulates the activity of dopamine neurons in the ventral tegmental area and regulates social memory formation.Frontiers in molecular neuroscience · 2024Article
- Liver Kinase B1 Functions as a Regulator for Neural Development and a Therapeutic Target for Neural Repair.Cells · 2022Review
- Polarity proteins: Shaping dendritic spines and memory.Developmental biology · 2022Review
- Metformin reduces neuroinflammation and improves cognitive functions after traumatic brain injury.Neuroscience research · 2021Article
- Memantine Improves Cognitive Function and Alters Hippocampal and Cortical Proteome in Triple Transgenic Mouse Model of Alzheimer's Disease.Experimental neurobiology · 2019Article
- Par3 regulates polarized convergence between APP and BACE1 in hippocampal neurons.Neurobiology of aging · 2019Article
- Loss of Par1b/MARK2 primes microglia during brain development and enhances their sensitivity to injury.Journal of neuroinflammation · 2019Article
- Role of Microtubule-Associated Protein in Autism Spectrum Disorder.Neuroscience bulletin · 2018Review
- Par3 and aPKC regulate BACE1 endosome-to-TGN trafficking through PACS1.Neurobiology of aging · 2017Article
- Microtubule affinity-regulating kinases are potential druggable targets for Alzheimer's disease.Cellular and molecular life sciences : CMLS · 2017Review
- Postsynaptic density 95 (PSD-95) serine 561 phosphorylation regulates a conformational switch and bidirectional dendritic spine structural plasticity.The Journal of biological chemistry · 2017Article
- Potential Role of Microtubule Stabilizing Agents in Neurodevelopmental Disorders.International journal of molecular sciences · 2017Review
- Tau phosphorylation at Alzheimer's disease-related Ser356 contributes to tau stabilization when PAR-1/MARK activity is elevated.Biochemical and biophysical research communications · 2016Article
- The polarity protein Par3 regulates APP trafficking and processing through the endocytic adaptor protein Numb.Neurobiology of disease · 2016Article
- Polarity Determinants in Dendritic Spine Development and Plasticity.Neural plasticity · 2016Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The Par1 kinases, also known as microtubule affinity-regulating kinases (MARKs), are important for the establishment of cell polarity from worms to mammals. Dysregulation of these kinases has been implicated in autism, Alzheimer's disease and cancer. Despite their important function in health and disease, it has been unclear how the activity of MARK/Par1 is regulated by signals from cell surface receptors. Here we show that MARK/Par1 is activated downstream of NMDA receptors in primary hippocampal neurons. Further, we show that this activation is dependent on protein kinase A (PKA), through the phosphorylation of Ser431 of Par4/LKB1, the major upstream kinase of MARK/Par1. Together, our data reveal a novel mechanism by which MARK/Par1 is activated at the neuronal synapse.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.