Genetic background influences loss of heterozygosity patterns in radiation-induced mouse thymic lymphoma.

Michael Hang, Yurong Huang, Antoine M Snijders, Jian-Hua Mao

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Article in Journal of nature and science. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact, top 97% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Michael HangLife Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA ; Undergraduate Program at Department of Molecular Cell Biology, University of California Berkeley, Berkeley, CA 94720, USA.

Yurong HuangLife Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA.

Antoine M SnijdersLife Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA.

Jian-Hua MaoLife Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA.

Lawrence Berkeley National Laboratory · US

Funding

The Role of Fbxw7 in genetic instability and cancerR01CA116481 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MAO, JIAN-HUA · 2008 to 2012

$1.7M

NCI NIH HHS R01 CA116481

6 · The paper itself

Abstract

Previous studies have revealed that p53 heterozygous (p53+/-) mice are extremely susceptible to radiation-induced tumorigenesis. To investigate whether genetic background influences radiation induced tumor susceptibility, we crossed p53+/- 129/Sv mice with genetically diverse strains to generate p53+/- F1 hybrids. The results showed that genetic background had a profound impact on tumor latency after exposure to gamma radiation, while the tumor spectrum did not change. We further characterized the thymic lymphomas that arose in the p53+/- mice by genome-wide loss of heterozygosity (LOH) analyses and found that genetic background strongly influenced the frequency of LOH and the loss of which parental allele on different chromosomes. Further research is needed to identify which genetic variations control the LOH patterns in radiation-induced thymic lymphomas and to evaluate its relevance to human cancers.

Indexed as

genetic susceptibilityionizing radiationloss of heterozygositythymic lymphoma

Identifiers

PMID25932465

PMCPMC4412163

OpenAlexW1568050560

What OpenQuestion holds

Textmetadata

LicenceTDM

Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.