ReviewAnnals of rehabilitation medicine2015
Aging of skeletal muscle fibers.
Review in Annals of rehabilitation medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03272737 (Effect of Low Intensity Strength Training Combined With Moderate Blood Flow Restriction on Muscle Vasodilatation and Arterial Stiffness in Elders With Low Gait Velocity.), which is not on this map. Cited by 156 papers, 6 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effect of Low Intensity Strength Training Combined With Moderate Blood Flow Restriction on Muscle Vasodilatation and Arterial Stiffness in Elders With Low Gait Velocity.
Who cites it
156 citing papers in PubMed, 6 syntheses or guidelines pooled it.
- Pooled it
- Muscle elasticity variations in assessing age-related changes in adults - A systematic review.Geriatrics & gerontology international · 2025Pooled it
- Effects of age on human skeletal muscle: a systematic review and meta-analysis of myosin heavy chain isoform protein expression, fiber size, and distribution.American journal of physiology. Cell physiology · 2024Pooled it
- AChRs Degeneration at NMJ in Aging-Associated Sarcopenia-A Systematic Review.Frontiers in aging neuroscience · 2020Pooled it
- Resistance training induced changes in strength and specific force at the fiber and whole muscle level: a meta-analysis.European journal of applied physiology · 2019Pooled it
- Effects of Jumping Exercise on Muscular Power in Older Adults: A Meta-Analysis.Sports medicine (Auckland, N.Z.) · 2018Pooled it
- Focused Electric Field Technology: A Novel Myoelectrical Stimulation Technology for Noninvasive Aging Muscle Rejuvenation.Journal of cosmetic dermatology · 2025Trial
- Effects of Supplemental Vitamin D3, Omega-3 Fatty Acids on Physical Performance Measures in the VITamin D and OmegA-3 TriaL.The Journal of clinical endocrinology and metabolism · 2024Trial
- Trial
- Vitamin DJournal of cachexia, sarcopenia and muscle · 2021Trial
- Associations of muscle lipid content with physical function and resistance training outcomes in older adults: altered responses with metformin.GeroScience · 2021Trial
- Trial
- Effects of Neuromuscular Electrical Stimulation Synchronized with Chewing Exercises on Bite Force and Masseter Muscle Thickness in Community-Dwelling Older Adults in South Korea: A Randomized Controlled Trial.International journal of environmental research and public health · 2020Trial
- Adaptations in mechanical muscle function, muscle morphology, and aerobic power to high-intensity endurance training combined with either traditional or power strength training in older adults: a randomized clinical trial.European journal of applied physiology · 2020Trial
- Low skeletal muscle capillarization limits muscle adaptation to resistance exercise training in older adults.Experimental gerontology · 2019Trial
- Passive thigh heating increases peak torque but does not attenuate declines in force production during repeated isokinetic knee extensor exercise in older adults.Physiological reports · 2026Article
- Cellular signaling within aged skeletal muscle reveals a dysregulated stress-induced remodeling response following volumetric muscle loss in female mice.Physiological reports · 2026Article
- Respiratory Muscle Performance and Pulmonary Function in Sarcopenic and Non-Sarcopenic Patients with Multiple Sclerosis: A Cross-Sectional Study.Healthcare (Basel, Switzerland) · 2026Article
- Comparative analysis of muscle pathologies and metabolic signaling in mouse models of mitochondrial dysfunction.Scientific reports · 2026Article
- Review
96 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Aging has become an important topic for scientific research because life expectancy and the number of men and women in older age groups have increased dramatically in the last century. This is true in most countries of the world including the Republic of Korea and the United States. From a rehabilitation perspective, the most important associated issue is a progressive decline in functional capacity and independence. Sarcopenia is partly responsible for this decline. Many changes underlying the loss of muscle mass and force-generating capacity of skeletal muscle can be understood at the cellular and molecular levels. Muscle size and architecture are both altered with advanced adult age. Further, changes in myofibers include impairments in several physiological domains including muscle fiber activation, excitation-contraction coupling, actin-myosin cross-bridge interaction, energy production, and repair and regeneration. A thorough understanding of these alterations can lead to the design of improved preventative and rehabilitative interventions, such as personalized exercise training programs.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.