ReviewIndian journal of endocrinology and metabolism
Feminizing adrenocortical tumors: Literature review.
Review in Indian journal of endocrinology and metabolism. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 33 citations in OpenAlex.
- Novel Insights Large Estrogen and Cortisol Co-Secreting Adrenocortical Tumor in a 17-Year-Old Female: A Case Report and Literature Review.Hormone research in paediatrics · 2026Article
- Feminizing Adrenocortical Carcinoma in Men: A Rare Cause of Persistent Gynecomastia and a Contemporary Literature Review.Epidemiologia (Basel, Switzerland) · 2025Article
- Late Diagnosis of Pregnancy in a Transmasculine Patient on Testosterone: A Case Report and Patient Perspective.Cureus · 2025Article
- A Dermatological Intervention of Gynecomastia in Young Asian Man with a History of Soy Product Consumption: A Case Report.International medical case reports journal · 2025Article
- Gynecomastia in adolescent males: current understanding of its etiology, pathophysiology, diagnosis, and treatment.Annals of pediatric endocrinology & metabolism · 2024Article
- Gynecomastia in a Man With Adrenal Mass.JCEM case reports · 2024Article
- Prepubertal Idiopathic Unilateral Gynecomastia: Case Report and Literature Review.Breast care (Basel, Switzerland) · 2022Article
- Estradiol-secreting adrenal oncocytoma in a 31-year old male.Urology case reports · 2022Article
- Feminizing Adrenocortical Tumors as a Rare Etiology of Isosexual/Contrasexual PseudopubertyJournal of clinical research in pediatric endocrinology · 2022Review
- Clinical utility of nuclear imaging in the evaluation of pediatric adrenal neoplasms.Frontiers in oncology · 2022Review
- Feminizing adrenocortical adenoma in a girl from a resource-limited setting: a case report.Journal of medical case reports · 2021Article
- The Case of Atypical Sexual Attractiveness in a Male Domestic Dog-A Case Study.Animals : an open access journal from MDPI · 2021Article
- Estrogen-secreting adrenocortical tumor in a postmenopausal woman: a challenging diagnosis.Endocrinology, diabetes & metabolism case reports · 2021Article
- Unique Sex Steroid Profiles in Estrogen-Producing Adrenocortical Adenoma Associated With Bilateral Hyperaldosteronism.Journal of the Endocrine Society · 2020Article
- Benign Feminizing Adrenal Tumor in an Adult Male.Ochsner journal · 2020Article
- Gynecomastia after euthyroidism restoration in a patient with type 1 diabetes and Graves' disease.Clinical case reports · 2018Article
- Feminizing Adrenocortical Carcinoma Without Gynecomastia.Oman medical journal · 2017Article
- Gynecomastia and hormones.Endocrine · 2017Review
- Feminizing Adrenocortical Tumor with Multiple Recurrences: A Case Report.Case reports in oncologyArticle
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Feminizing adrenal tumors (FAT) are extremely rare tumors prevailing in males. Clinical manifestations are gynecomastia and/or other hypogonadism features in adults. They are rarer in pediatric population and their main manifestation is peripheral sexual precocity. In women genital bleeding, uterus hypertrophy, high blood pressure and/or abdomen mass may be the only manifestations. On the biological point, estrogen overproduction with or without increase in other adrenal hormones are the main abnormalities. Radiological examination usually shows the tumor, describes its limits and its eventual metastases. Adrenal and endocrine origins are confirmed by biochemical assessments and histology, but that one is unable to distinguish between benign and malignant tumors, except if metastases are already present. Immunostaining using anti-aromatase antibodies is the only tool that distinguishes FAT from other adrenocortical tumors. Abdominal surgery is the best and the first line treatment. For large tumors (≥10 cm), an open access is preferred to coeliosurgery, but for the small ones, or when the surgeon is experienced, endoscopic surgery seems to give excellent results. Surgery can be preceded by adrenolytic agents such as ortho paraprime dichloro diphenyl dichloroethane (Mitotane), ketoconazole or by aromatase inhibitors, but till now there is not any controlled study to compare the benefit of different drugs. New anti-estrogens can be used too, but their results need to be confirmed in malignant tumors resistant to classical chemotherapy and to conventional radiotherapy. Targeted therapy can be used too, as in other adrenocortical tumors, but the results need to be confirmed.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.