Evidence map›Paper›PMID 25932337›Full record

ArticleJournal of periodontal & implant science2015

The effect of photodynamic therapy on Aggregatibacter actinomycetemcomitans attached to surface-modified titanium.

Kyungwon Cho, Si Young Lee, Beom-Seok Chang, Heung-Sik Um, Jae-Kwan Lee

Abstract read
In one paragraph

Article in Journal of periodontal & implant science, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Photodynamic Therapy for Peri-Implant Diseases.Antibiotics (Basel, Switzerland) · 2022
    Review
  4. Article
  5. Review
  6. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Kyungwon ChoDepartment of Periodontology, Research Institute for Oral Sciences, College of Dentistry, Gangneung-Wonju National University, Gangneung, Korea.ORCID 0000-0001-7236-4020
Si Young LeeDepartment of Oral Microbiology, Research Institute for Oral Sciences, College of Dentistry, Gangneung-Wonju National University, Gangneung, Korea.ORCID 0000-0001-8826-1413
Beom-Seok ChangDepartment of Periodontology, Research Institute for Oral Sciences, College of Dentistry, Gangneung-Wonju National University, Gangneung, Korea.ORCID 0000-0002-5280-3249
Heung-Sik UmDepartment of Periodontology, Research Institute for Oral Sciences, College of Dentistry, Gangneung-Wonju National University, Gangneung, Korea.ORCID 0000-0002-7986-1019
Jae-Kwan LeeDepartment of Periodontology, Research Institute for Oral Sciences, College of Dentistry, Gangneung-Wonju National University, Gangneung, Korea.ORCID 0000-0003-1710-1580

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThe purpose of this study was to evaluate the effect of photodynamic therapy (PDT) using erythrosine and a green light emitting diode (LED) light source on biofilms of Aggregatibacter actinomycetemcomitans attached to resorbable blasted media (RBM) and sandblasted, large-grit, acid-etched (SLA) titanium surfaces in vitro.

methodsRBM and SLA disks were subdivided into four groups, including one control group and three test groups (referred to as E0, E30, E60), in order to evaluate the effect of PDT on each surface. The E0 group was put into 500 µL of 20 µM erythrosine for 60 seconds without irradiation, the E30 group was put into erythrosine for 60 seconds and was then irradiated with a LED for 30 seconds, and the E60 group was put into erythrosine for 60 seconds and then irradiated with a LED for 60 seconds. After PDT, sonication was performed in order to detach the bacteria, the plates were incubated under anaerobic conditions on brucella blood agar plates for 72 hours at 37℃, and the number of colony-forming units (CFUs) was determined.

resultsSignificant differences were found between the control group and the E30 and E60 groups (P<0.05). A significantly lower quantity of CFU/mL was found in the E30 and E60 groups on both titanium disk surfaces. In confocal scanning laser microscopy images, increased bacterial death was observed when disks were irradiated for a longer period of time.

conclusionsThese findings suggest that PDT using erythrosine and a green LED is effective in reducing the viability of A. actinomycetemcomitans attached to surface-modified titanium in vitro.

Indexed as

Bacterial viabilityErythrosinePhotodynamic therapyTitanium

Identifiers

PMID25932337
PMCPMC4415000

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.