ReviewOpen heart
Guilt by association: paradigm for detecting a silent killer (thoracic aortic aneurysm).
Review in Open heart. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
38 citing papers in PubMed, 1 synthesis or guideline pooled it, 104 citations in OpenAlex.
- Endovascular versus conventional open surgical repair for thoracoabdominal aortic aneurysms.The Cochrane database of systematic reviews · 2022Pooled it
- Influence of Hypertension on the Regional Elastic Properties of Ascending Thoracic Aortic Aneurysms with Bicuspid Aortic Valves.Annals of biomedical engineering · 2026Article
- Simple Renal Cysts and Aortic Aneurysms: From Imaging Markers to Prognostic Indicators of Postoperative Outcomes.Annals of vascular diseases · 2026Review
- Mendelian Randomization Suggests a Causal Link Between Glycemic Traits and Thoracic Aortic Structures and Diseases.JACC. Basic to translational science · 2025Article
- Dysphagia Aortica: An Uncommon and Potentially Life-Threatening Condition.GE Portuguese journal of gastroenterology · 2023Article
- Label-free quantitative proteomic analysis of serum exosomes in mice with thoracic aortic aneurysm.Proteome science · 2023Article
- Statistical shape representation of the thoracic aorta: accounting for major branches of the aortic arch.Computer methods in biomechanics and biomedical engineering · 2023Article
- Identification of apoptosis-related key genes and the associated regulation mechanism in thoracic aortic aneurysm.BMC cardiovascular disorders · 2023Article
- The Role of ADAMTS Proteoglycanases in Thoracic Aortic Disease.International journal of molecular sciences · 2023Review
- Changes in transmural mass transport correlate with ascending thoracic aortic aneurysm diameter in a fibulin-4 E57K knockin mouse model.American journal of physiology. Heart and circulatory physiology · 2023Article
- Role of non-coding variants in cardiovascular disease.Journal of cellular and molecular medicine · 2023Review
- Screening for the vulnerable aorta: targeting high-risk groups in the population.The British journal of cardiology · 2023Article
- Risk Prediction Models for Management of Patients following Acute Aortic Dissection.Aorta (Stamford, Conn.) · 2022Article
- Tracking an Elusive Killer: State of the Art of Molecular-Genetic Knowledge and Laboratory Role in Diagnosis and Risk Stratification of Thoracic Aortic Aneurysm and Dissection.Diagnostics (Basel, Switzerland) · 2022Review
- Gender differences in the dissection properties of ascending thoracic aortic aneurysms.Interactive cardiovascular and thoracic surgery · 2022Article
- Diagnosis of fast-growing thoracic aneurysm with microscopic evidence of dissection over 6 months follow-up in an asymptomatic middle aged gentleman: a case report.BMC cardiovascular disorders · 2022Article
- High Prevalence of Thoracic Aortic Dilatation in Men with Previous Inguinal Hernia Repair.Aorta (Stamford, Conn.) · 2022Article
- Article
- Aortic gene dictionary in the precision medicine era-update from the Aortic Institute at Yale New Haven.Indian journal of thoracic and cardiovascular surgery · 2022Article
- Flow displacement and decreased wall shear stress might be associated with the growth rate of an ascending aortic dilatation.European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recent studies have confirmed a close association between various medical conditions (intracranial aneurysm, abdominal aortic aneurysm, temporal arteritis, autoimmune disorder, renal cysts), certain aortic anatomic variants (bovine aortic arch, direct origin of left vertebral artery from aortic arch, bicuspid aortic valve), and family history of aneurysm disease with thoracic aortic aneurysm and dissection. This paper reviews these associations. We propose to capitalise on these associations as powerful and expanding opportunities to diagnose the virulent but silent disease of thoracic aortic aneurysm. This can be accomplished by recognition of this 'guilt by association' with the other conditions. Thus, patients with associated diseases and anatomic variants should be investigated for silent aortic aneurysms. Such a paradigm holds substantial potential for reducing death from the silent killer represented by thoracic aortic aneurysm disease.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.