Association between NKX2-5 rs29784 and infantile hypertrophic pyloric stenosis in Chinese Han population.

Zhiqiang Feng, Peizhi Liang, Qingning Li, Yuqiang Nie, Youxiang Zhang

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In one paragraph

Article in International journal of clinical and experimental medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it

0cells of the map it votes in

2citing papers in PubMed

0.3field-weighted citation impact, top 40% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

Co-occurrence of infantile hypertrophic pyloric stenosis and congenital heart defects: a nationwide cohort study.Pediatric research · 2019
Article
A novel missense mutation in the transcription factor FOXF1 cosegregating with infantile hypertrophic pyloric stenosis in the extended pedigree linked to IHPS5 on chromosome 16q24.Pediatric research · 2017
Article

4 · The record

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5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Zhiqiang FengDepartment of Gastroenterology, Guangzhou First People's Hospital, Guangzhou Medical University, Guangzhou Digestive Disease Center Guangzhou, China ; Guangzhou Key Laboratory of Digestive Disease, Guangzhou First People's Hospital, Guangzhou Medical University Guangzhou, China.

Peizhi LiangDepartment of Gastroenterology, Guangzhou First People's Hospital, Guangzhou Medical University, Guangzhou Digestive Disease Center Guangzhou, China ; Guangzhou Key Laboratory of Digestive Disease, Guangzhou First People's Hospital, Guangzhou Medical University Guangzhou, China.

Qingning LiDepartment of Gastroenterology, Guangzhou First People's Hospital, Guangzhou Medical University, Guangzhou Digestive Disease Center Guangzhou, China ; Guangzhou Key Laboratory of Digestive Disease, Guangzhou First People's Hospital, Guangzhou Medical University Guangzhou, China.

Yuqiang NieDepartment of Gastroenterology, Guangzhou First People's Hospital, Guangzhou Medical University, Guangzhou Digestive Disease Center Guangzhou, China ; Guangzhou Key Laboratory of Digestive Disease, Guangzhou First People's Hospital, Guangzhou Medical University Guangzhou, China.

Youxiang ZhangDepartment of Pediatrics, Guangzhou First People's Hospital, Guangzhou Medical University Guangzhou, China.

First Affiliated Hospital of Guangzhou Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThe aim of this study was to evaluate the association of three single nucleotide polymorphisms (SNPs, rs11712066 and rs573872 near MBNL1, rs29784 near NKX2-5) with infantile hypertrophic pyloric stenosis (IHPS) in Chinese Han population.

methodsA total of 47 family trios consisting of infants with IHPS and their healthy biological parents were recruited for this study. Genotypes were determined using direct sequencing. Transmission disequilibrium test (TDT) was performed for family-based association analysis.

resultsGenotypic distributions of three SNPs in both groups (patients and proband's parents) were in conformity with Hardy-Weinberg equilibrium (P > 0.05). There were significant preferential transmission of A allele of rs29784 from the parents to affected offspring (TDT: x(2) = 5.444, P = 0.0196). However, other two polymorphism loci (rs11712066 and rs573872) were not significant susceptibility loci for IHPS in Chinese Han population.

conclusionsWe found that there was a significant association between rs29784 and IHPS.

Indexed as

Infantile hypertrophic pyloric stenosisrs29784single nucleotide polymorphismtransmission disequilibrium test

Identifiers

PMID25932253

PMCPMC4402900

OpenAlexW392699523

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.