ArticleInternational journal of clinical and experimental medicine2015
Expression of the microRNAs hsa-miR-15a and hsa-miR-16-1 in lens epithelial cells of patients with age-related cataract.
Article in International journal of clinical and experimental medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
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Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it, 49 citations in OpenAlex.
- A comprehensive investigation of identifying miRNA biomarkers and their potential role in age-related cataract by meta-analysis and bioinformatics analysis.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2025Pooled it
- Crucial involvement of transforming growth factor beta (TGF-β)/Smad signaling regulation by miR-204-5p in cataract and posterior capsular opacification.Biochemistry and biophysics reports · 2026Review
- Dysregulated MicroRNAs in Parkinson's Disease: Pathogenic Mechanisms and Biomarker Potential.International journal of molecular sciences · 2026Article
- Aging of the human eye lens: Epigenetic landscape and therapeutic targets in age‑related cataracts (Review).International journal of molecular medicine · 2025Review
- Effect of Crocin and Crocetin Compared to Cyclophosphamide on the Expression Level of miRNA-16-1 in a B Cell Transformed with EBV Virus Cell Line.Asian Pacific journal of cancer prevention : APJCP · 2024Article
- Mir-204-5p alleviates mitochondrial dysfunction by targeting IGFBP5 in diabetic cataract.Molecular biology reports · 2024Article
- Plasma miR-19b, miR-34a, and miR-146a expression in patients with type 2 diabetes mellitus and cataract: A pilot study.Biomolecules & biomedicine · 2024Article
- MicroRNA-22-3p Regulates the Apoptosis of Lens Epithelial Cells Through Targeting KLF6 in Diabetic Cataracts.Translational vision science & technology · 2023Article
- Suppressive effects of umbilical cord mesenchymal stem cell-derived exosomal miR-15a-5p on the progression of cholangiocarcinoma by inhibiting CHEK1 expression.Cell death discovery · 2022Article
- Screening of Biological Target Molecules Related to Glucocorticoid-Induced Cataract (GIC) on the Basis of Constructing ceRNA Network.Biochemical genetics · 2022Article
- Article
- Investigation of MicroRNA Expression in Anterior Lens Capsules of Senile Cataract Patients and MicroRNA Differences According to the Cataract Type.Translational vision science & technology · 2021Article
- TGF-β regulation of microRNA miR-497-5p and ocular lens epithelial cell mesenchymal transition.Science China. Life sciences · 2020Article
- MicroRNAs in the Vitreous Humor of Patients with Retinal Detachment and a Different Grading of Proliferative Vitreoretinopathy: A Pilot Study.Translational vision science & technology · 2020Article
- MicroRNA-15a modulates lens epithelial cells apoptosis and proliferation through targeting B-cell lymphoma-2 and E2F transcription factor 3 in age-related cataracts.Bioscience reports · 2019Article
- The expression levels of miRNA-15a and miRNA-16-1 in circulating tumor cells of patients with diffuse large B-cell lymphoma.Molecular biology reports · 2019Article
- miR‑15a‑3p affects the proliferation, migration and apoptosis of lens epithelial cells.Molecular medicine reports · 2019Article
- A splice-site variant in the lncRNA geneMolecular vision · 2019Article
- Effects of UV on apoptotic factors in lens epithelial cells of an animal model.Experimental and therapeutic medicine · 2018Article
- Therapeutic potential of a dual mTORC1/2 inhibitor for the prevention of posterior capsule opacification: An in vitro study.International journal of molecular medicine · 2018Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study aimed to examine and analyze the expression levels of hsa-miR-15a and hsa-miR-16-1 in lens epithelial cells from patients with age-related cataract to understand better the roles of these microRNAs in the pathogenesis of this disease. Lens epithelial cells of 60 age-related cataract patients (including 20 with cortical cataracts, 20 with nuclear cataracts, and 20 with posterior subcapsular cataracts) and 20 normal patients were included in the study. Real-time PCR was used to detect the expression of hsa-miR-15a-5p, hsa-miR-15a-3p, hsa-miR-16-1-5p, and hsa-miR-16-1-3p. Expression of the target genes of these microRNAs, namely bcl-2 and mcl-1, was also evaluated. hsa-miR-15a-5p, hsa-miR-15a-3p, and hsa-miR-16-1-5p were expressed at low levels in normal lens epithelial cells but at significantly higher levels in corresponding cells of patients with cortical, nuclear, or posterior subcapsular cataracts (P < 0.01). hsa-miR-16-1-3p was expressed at relatively high levels in normal lens epithelial cells but significantly decreased expression, or none at all, was detected in cells of patients from each cataract group (P < 0.01). Concerning their target genes bcl-2 and mcl-1, expression was detectable in normal lens epithelial cells, but their levels were significantly decreased in cataract patients, irrespective of type (P < 0.01). Expression of hsa-miR-15a-5p, hsa-miR-15a-3p, and hsa-miR-16-1-5p rose in lens epithelial cells in the three types of age-related cataract, which may suppress the expression of the anti-apoptotic genes bcl-2 and mcl-1, thereby contributing to the pathogenesis of age-related cataract through apoptosis.
Indexed as
Identifiers
25932180PMC4402827W2418856471What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.