ArticleInternational journal of clinical and experimental medicine2015
Association between tumor necrosis factor alpha rs1800629 polymorphism and risk of cervical cancer.
Article in International journal of clinical and experimental medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed, 1 synthesis or guideline pooled it, 8 citations in OpenAlex.
- Association between tumor necrosis factor-α gene polymorphisms and diffuse large B-cell lymphoma in Chinese Han population: evidence from two center case-control study and a meta-analysis.International journal of clinical and experimental pathology · 2015Pooled it
- Effects of Long-Term Vitamin D Supplementation on Regression and Metabolic Status of Cervical Intraepithelial Neoplasia: a Randomized, Double-Blind, Placebo-Controlled Trial.Hormones & cancer · 2017Trial
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe objective of this study was to evaluate the influence of the TNF-α rs1800629 polymorphism on the risk of cervical cancer.
methodsA comprehensive search of EMBASE, PubMed, Wanfang database and China National Knowledge Infrastructure (CNKI) was conducted and the papers published were retrieved. The fixed effects or random effects model was appropriately used to calculate the odds ratio (OR) along with 95% confidence interval (CI).
resultsData from sixteen articles containing nineteen studies were summarized in this meta-analysis. In general, we observed a marginal association between the TNF-α rs1800629 polymorphism and cervical cancer risk under the AA + AG vs. GG comparison model (OR=1.17, 95% CI=1.00-1.38, P=0.019 for heterogeneity). Interestingly, significantly increased risk was observed in the allele model (A vs. G: OR=1.19, 95% CI=1.02-1.38, P=0.006 for heterogeneity). In the stratified analysis by ethnicity, we found significant results in Caucasians.
conclusionsOur results reveal that the Caucasian population may be at increased risk of developing invasive cervical cancer associated with the TNF-α rs1800629 polymorphism.
Indexed as
Identifiers
25932141PMC4402788W2395184941What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.