ArticleInternational journal of clinical and experimental medicine2015
Prognostic value of ALDH1 expression in lung cancer: a meta-analysis.
Article in International journal of clinical and experimental medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.
- The Clinical Significance and Prognostic Value of ALDH1 Expression in Non-small Cell Lung Cancer: A Systematic Review and Meta-analysis.Recent patents on anti-cancer drug discovery · 2024Pooled it
- Targeting Lipid Metabolism in Cancer Stem Cells for Anticancer Treatment.International journal of molecular sciences · 2024Review
- Mitochondrial VDAC1 Silencing in Urethane-Induced Lung Cancer Inhibits Tumor Growth and Alters Cancer Oncogenic Properties.Cancers · 2024Article
- The biological roles of CD47 in ovarian cancer progression.Cancer immunology, immunotherapy : CII · 2024Review
- Review
- Article
- ALDH1 and SALL4 Expression in Cell Block Samples from Patients with Lung Adenocarcinoma and Malignant Pleural Effusion.Diagnostics (Basel, Switzerland) · 2021Article
- Aldehyde dehydrogenase 1B1 is a potential marker of colorectal tumors.Histology and histopathology · 2021Article
- The SOX9-Aldehyde Dehydrogenase Axis Determines Resistance to Chemotherapy in Non-Small-Cell Lung Cancer.Molecular and cellular biology · 2020Article
- Spectrum ofArchives of medical science : AMS · 2020Article
- Triple-Negative Breast Cancer: Current Understanding and Future Therapeutic Breakthrough Targeting Cancer Stemness.Cancers · 2019Review
- The expressions of CD133, ALDH1, and vasculogenic mimicry in osteosarcoma and their clinical significance.International journal of clinical and experimental pathology · 2018Article
- Aberrant expression of ALDH1, MMP9, Integrin αvβ3, and KiSS-1 in invasive ductal carcinoma and their clinical significance.International journal of clinical and experimental pathology · 2018Article
- NRP1-positive lung cancer cells possess tumor-initiating properties.Oncology reports · 2018Article
- Drug Resistance Driven by Cancer Stem Cells and Their Niche.International journal of molecular sciences · 2017Review
- Evaluation of the correlation of vasculogenic mimicry, ALDH1, KAI1 and microvessel density in the prediction of metastasis and prognosis in colorectal carcinoma.BMC surgery · 2017Article
- Evaluation of the correlation of vasculogenic mimicry, ALDH1, KiSS-1, and MACC1 in the prediction of metastasis and prognosis in ovarian carcinoma.Diagnostic pathology · 2017Article
- The prognostic roles of ALDH1 isoenzymes in gastric cancer.OncoTargets and therapy · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveALDH1 has recently been reported as a marker of cancer stem-like cells in lung cancer. However, the predictive value of ALDH1 in lung cancer remains controversial. In this study, we aimed to evaluate the association of ALDH1 expression with the clinicopathological features and outcomes of lung cancer patients through a meta-analysis.
methodsPublications that assessed the clinical or prognostic significance of ALDH1 in lung cancer up to October 2014 were identified. A meta-analysis was performed to clarify the association between ALDH1 expression and clinical outcomes.
resultsTen eligible publications with 1836 patients were included. The analysis of these data showed that ALDH1 expression was highly correlated with lymph node metastasis (pooled OR = 1.45, 95% CI: 1.04-2.02, P = 0.027), decreased overall survival (pooled RR: 2.25, 95% CI: 1.15-4.41, P = 0.019), and decreased disease-free survival (pooled RR: 1.63, 95% CI: 1.01-2.64, P = 0.047).
conclusionPatients with ALDH1-positive lung cancer had poor prognosis, which was associated with common clinicopathological poor prognostic factors.
Indexed as
Identifiers
25932135PMC4402782W2189367998What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.