ArticleInternational journal of clinical and experimental medicine2015
Polymorphisms of interleukin-10 genes on the risk of ischemic stroke in a meta-analysis.
Article in International journal of clinical and experimental medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
6 citing papers in PubMed, 2 syntheses or guidelines pooled it, 7 citations in OpenAlex.
- The Role of Genetics in Stroke Risk and Outcome: A Review of Current Evidence.Brain and behavior · 2025Pooled it
- Pooled it
- Inflammatory Profiles of the Interleukin Family and Network in Cerebral Hemorrhage.Cellular and molecular neurobiology · 2018Review
- Role of Interleukin-10 in Acute Brain Injuries.Frontiers in neurology · 2017Review
- Association between genetic polymorphisms of interleukins and cerebral infarction risk: a meta-analysis.Bioscience reports · 2016Article
- Association between IL-10 gene polymorphisms and the risk of ischemic stroke in a Chinese population.International journal of clinical and experimental pathology · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPrevious studies have investigated the associations between polymorphisms of interleukin-10 (IL-10) gene and risk of ischemic stroke (IS). However, the results were inconsistent. The aim of this study was to clarify the relationship between IL-10 polymorphisms and IS risk by a meta-analysis approach.
methodsThe meta-analysis was performed by searching PubMed and Wanfang databases. Odds ratio (OR) and corresponding 95% confidence interval (95% CI) as well as effect size were calculated by a fixed or random-effect model according to the I(2) value. In total, five case-control studies for IL10-1082G/A and four studies for IL10-819C/T were included in this meta-analysis.
resultsCombined analysis indicated that IL10-1082G/A polymorphism was associated with risk of IS (A/A vs. G/G+G/A: OR = 1.82, 95% CI = 1.21-2.74, P = 0.004; for A allele vs. G allele: OR = 1.55, 95% CI = 1.14-2.10, P = 0.006). However, there was no significant association between IL10-819C/T polymorphism and IS in any comparison model (C/C vs. T/C+T/T: OR = 0.96, 95% CI = 0.69-1.36, P = 0.84; C allele vs. T allele: OR = 1.00, 95% CI = 0.83-1.21, P = 0.97).
conclusionsOur results indicated that IL-10-1082G/A polymorphism, but not IL10-819C/T polymorphism was associated with the risk of IS.
Indexed as
Identifiers
25932117PMC4402764W2415997939What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.