ArticleInternational journal of clinical and experimental medicine2015
MicroRNA-506 suppresses growth and metastasis of oral squamous cell carcinoma via targeting GATA6.
Article in International journal of clinical and experimental medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The trial behind it
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Who cites it
23 citing papers in PubMed, 38 citations in OpenAlex.
- EBV-Induced LINC00944: A Driver of Oral Cancer Progression and Influencer of Macrophage Differentiation.Cancers · 2025Article
- MicroRNA-10a-5p-mediated downregulation of GATA6 inhibits tumor progression in ovarian cancer.Human cell · 2024Article
- MiRNA-related metastasis in oral cancer: moving and shaking.Cancer cell international · 2023Review
- Pathogenesis and prognosis of primary oral squamous cell carcinoma based on microRNAs target genes: a systems biology approach.Genomics & informatics · 2022Article
- YY1 accelerates oral squamous cell carcinoma progression through long non-coding RNA Kcnq1ot1/microRNA-506-3p/SYPL1 axis.Journal of ovarian research · 2022Article
- GATA6‑induced FN1 activation promotes the proliferation, invasion and migration of oral squamous cell carcinoma cells.Molecular medicine reports · 2022Article
- MicroRNA-487a-3p inhibits the growth and invasiveness of oral squamous cell carcinoma by targeting PPM1A.Bioengineered · 2021Article
- Article
- The expression of the GATA6 gene in oral carcinoma cell lines.World journal of surgical oncology · 2021Article
- Aberrant Expression of miR-103, miR-184, miR-378, miR-497 and miR-506 in Tumor Tissue from Patients with Oral Squamous Cell Carcinoma Regulates the Clinical Picture of the Patients.Asian Pacific journal of cancer prevention : APJCP · 2020Article
- SerpinB2 inhibits migration and promotes a resolution phase signature in large peritoneal macrophages.Scientific reports · 2019Article
- miR-506 contributes to malignancy of cutaneous squamous cell carcinoma via targeting of P65 and LAMC1.Cell cycle (Georgetown, Tex.) · 2019Article
- GATA6 suppresses migration and metastasis by regulating the miR-520b/CREB1 axis in gastric cancer.Cell death & disease · 2019Article
- circPCNX and Pecanex Promote Hepatocellular Carcinoma Cell Viability by Inhibiting miR-506.Cancer management and research · 2019Article
- Evaluation of miR-506 and miR-4316 expression in early and non-invasive diagnosis of colorectal cancer.International journal of colorectal disease · 2017Article
- The emerging role of miR-506 in cancer.Oncotarget · 2016Review
- Non-coding RNAs deregulation in oral squamous cell carcinoma: advances and challenges.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2016Review
- miR-506 inhibits cell proliferation and invasion by targeting TET family in colorectal cancer.Iranian journal of basic medical sciences · 2016Article
- Application of plasma circulating microRNA-448, 506, 4316, and 4478 analysis for non-invasive diagnosis of lung cancer.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2016Article
- miR-124 and miR-506 inhibit colorectal cancer progression by targeting DNMT3B and DNMT1.Oncotarget · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Oral squamous cell carcinoma (OSCC) remains the main cause of cancer mortality, accounts for 90% of oral cancers. Increasing evidence reveals that aberrant expression of microRNA contributes to the development and progression of OSCC, but the roles of microRNA-506 (miR-506) in OSCC remain elusive. Here, we found that the expression of miR-506 was decreased in 21 OSCC tissues and SCC-4 and SCC-9 cells. miR-506 overexpression suppressed proliferation, migration and invasion capabilities of OSCC cells. Moreover, miR-506 overexpression suppressed the luciferase activity of the GATA6-Wt 3'-UTR and decreased the mRNA and protein levels of GATA6. GATA6 overexpression attenuated the suppressive effects of miR-506. Furthermore, GATA6 was increased in OSCC tissues compared with the adjacent normal tissues and inversely associated with miR-506. Taken together, these results suggest that miR-506 is an important suppressor and could be a novel prognostic factor and therapeutic target for OSCC patients.
Indexed as
Identifiers
25932114PMC4402761W2403328652What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.