Ameliorating effects of low tidal volume ventilation with associated hypercapnia on pneumoperitoneum-induced lung injury by inhibition of Toll-like receptor 4.

Shenqiang Gao, Shanhui Guan, Hongyan Li, Aiping Su, Yuelan Wang

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In one paragraph

Article in International journal of clinical and experimental medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

0.2field-weighted citation impact, top 41% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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1 citing paper in PubMed, 1 citations in OpenAlex.

Perioperative "remote" acute lung injury: recent update.Journal of biomedical research · 2017
Article

4 · The record

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5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Shenqiang GaoDepartment of Anesthesiology, Qianfoshan Hospital Affiliated to Shandong University Jinan 250014, China ; Department of Anesthesiology, The Central Hospital of Taian Taian 271000, China.

Shanhui GuanDepartment of Anesthesiology, The Central Hospital of Taian Taian 271000, China.

Hongyan LiDepartment of Anesthesiology, The Central Hospital of Taian Taian 271000, China.

Aiping SuDepartment of Nephrology, Taishan Hospital of Shandong Province Taian 271000, China.

Yuelan WangDepartment of Anesthesiology, Qianfoshan Hospital Affiliated to Shandong University Jinan 250014, China.

Shandong Provincial QianFoShan Hospital · CNTaian City Central Hospital · CNAffiliated Hospital of Taishan Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMechanical ventilation using lower tidal volume ventilation with associated hypercapnia is supported to avoid ventilator-induced lung injury, but the underlying mechanism is not clear. This study was intended to explore whether low tidal volume ventilation with associated hypercapnia would ameliorate pneumoperitoneum-induced lung injury and whether this protection strategy might work through mediating inflammation and oxidative stress via TLR 4 signaling pathway. MATERIALS AND

methods50 anesthetized Wistar Rats were randomized to be mechanically ventilated for 4 h at 7 groups: Group A, ventilated with 12 ml/kg; Group B, similar to Group A but injected with LPS (Toll receptor 4 agonist); Group C, similar to Group A but injected with Pam3Cys (Toll receptor 2 agonist); Group D, ventilated with 12 ml/kg and subjected to pneumoperitoneum; Group E, ventilated with 6 ml/kg and subjected to pneumoperitoneum; Group F, similar to Group E but injected with LPS; Group G, similar to Group E but injected with Pam3Cys. After animals were killed, indices of lung Injury, inflammation markers and oxidative stress markes of the lungs tissues, bronchoalveolar lavage fluid and blood were assessed.

resultsThe group subjected to pneumoperitoneum (Group D) had elevated values of indices of lung Injury, inflammation oxidative stress markers compared with the controls (Group A). The low tidal volume ventilation group (Group E) had significantly decreased values of markers of lung Injury, inflammation and oxidative stress compared with the high tidal volume ventilation group (Group D). LPS treatment reversed all the results of Group E, while Pam3Cys treatment had no significant effect.

conclusionsLow tidal volume ventilation with associated hypercapnia ameliorated pneumoperitoneum-induced lung injury by reducing TLR 4-mediated inflammation and oxidative stress.

Indexed as

hypercapniaLow tidal volume ventilationlung injurypneumoperitoneumToll-like receptor 4

Identifiers

PMID25932109

PMCPMC4402756

OpenAlexW392655852

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.